Cell Biology Antibodies 13
Anti-BAZ2A / TIP5 Antibody (CAB17629)
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- SKU:
- CAB17629
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-BAZ2A / TIP5 Antibody |
| Antibody SKU: | CAB17629 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein of Human BAZ2A?TIP5?. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | K-562, HeLa, NIH/3T3 |
| Immunogen: | Recombinant fusion protein of Human BAZ2A?TIP5?. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 11176 |
| Uniprot: | Q9UIF9 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | 280kDa |
 | Western blot - BAZ2A / TIP5 Polyclonal Antibody (CAB17629) |
| Synonyms: | TIP5, WALp3, BAZ2A / TIP5, BAZ2A |
| Background: |
| UniProt Protein Function: | Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing. |
| UniProt Code: | Q9UIF9 |
| NCBI GenInfo Identifier: | 91176325 |
| NCBI Gene ID: | 11176 |
| NCBI Accession: | NP_038477.2 |
| UniProt Secondary Accession: | Q9UIF9,O00536, O15030, Q68DI8, Q96H26, B3KN66, |
| UniProt Related Accession: | Q9UIF9 |
| Molecular Weight: | 210,747 Da |
| NCBI Full Name: | bromodomain adjacent to zinc finger domain protein 2A isoform 1 |
| NCBI Synonym Full Names: | bromodomain adjacent to zinc finger domain 2A |
| NCBI Official Symbol: | BAZ2A |
| NCBI Official Synonym Symbols: | TIP5; WALp3 |
| NCBI Protein Information: | bromodomain adjacent to zinc finger domain protein 2A |
| UniProt Protein Name: | Bromodomain adjacent to zinc finger domain protein 2A |
| UniProt Synonym Protein Names: | Transcription termination factor I-interacting protein 5; TTF-I-interacting protein 5; Tip5; hWALp3 |
| UniProt Gene Name: | BAZ2A |
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