Immunology Antibodies 1

Anti-BANK1 Antibody (CAB10312)

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SKU:
CAB10312
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-BANK1 Antibody
Antibody SKU:CAB10312
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 516-785 of human BANK1 (NP_060405.4).
Application:WB
Recommended Dilution:WB 1:1000 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:B cells, Raji, U-87MG, A-549, 22Rv1, HepG2, Mouse liver, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 516-785 of human BANK1 (NP_060405.4).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:PVAN AFQL ERPH FTLP GTMV EGQM ERSQ NWGH PGVR QETG DEPK GEKE KKEE EKEQ EEEE DPYT FAEI DDSE YDMI LANL SIKK KTGS RSFI INRP PAPT PRPT SIPP KEET TPYI AQVF QQKT ARRQ SDDD KFRG LPKK QDRA RIES PAFS TLRG CLTD GQEE LILL QEKV KNGK MSMD EALE KFKH WQMG KSGL EMIQ QEKL RQLR DCII GKRP EEEN VYNK LTIV HHPG GKET AHNE NKFY NVHF SNKL PARP QVEK EFGF CCKK DH
Gene ID:55024
Uniprot:Q8NDB2
Cellular Location:
Calculated MW:73kDa/86kDa/88kDa/89kDa
Observed MW:89kDa
Synonyms:BANK1, BANK
Background:The protein encoded by this gene is a B-cell-specific scaffold protein that functions in B-cell receptor-induced calcium mobilization from intracellular stores. This protein can also promote Lyn-mediated tyrosine phosphorylation of inositol 1, 4, 5-trisphosphate receptors. Polymorphisms in this gene are associated with susceptibility to systemic lupus erythematosus. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:BANK1: Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2. Genetic variations in BANK1 influence susceptibility to systemic lupus erythematosus (SLE). SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Adaptor/scaffold

Chromosomal Location of Human Ortholog: 4q24

Disease: Systemic Lupus Erythematosus

NCBI Summary:The protein encoded by this gene is a B-cell-specific scaffold protein that functions in B-cell receptor-induced calcium mobilization from intracellular stores. This protein can also promote Lyn-mediated tyrosine phosphorylation of inositol 1,4,5-trisphosphate receptors. Polymorphisms in this gene are associated with susceptibility to systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
UniProt Code:Q8NDB2
NCBI GenInfo Identifier:308153627
NCBI Gene ID:55024
NCBI Accession:Q8NDB2.3
UniProt Secondary Accession:Q8NDB2,Q8N5K8, Q8NB56, Q8WYN5, Q9NWP2, A8K7W8, B0F3S2
UniProt Related Accession:Q8NDB2
Molecular Weight:73,674 Da
NCBI Full Name:B-cell scaffold protein with ankyrin repeats
NCBI Synonym Full Names:B-cell scaffold protein with ankyrin repeats 1
NCBI Official Symbol:BANK1  
NCBI Official Synonym Symbols:BANK  
NCBI Protein Information:B-cell scaffold protein with ankyrin repeats
UniProt Protein Name:B-cell scaffold protein with ankyrin repeats
Protein Family:B-cell scaffold protein with ankyrin repeats
UniProt Gene Name:BANK1  
UniProt Entry Name:BANK1_HUMAN
Anti-BANK1 Antibody (CAB10312)Western blot analysis of extracts of various cell lines, using BANK1 antibody (CAB10312) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3s.
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