Cell Biology Antibodies 4

Anti-BAMBI Antibody (CAB13589)

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SKU:
CAB13589
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-BAMBI Antibody
Antibody SKU:CAB13589
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 21-152 of human BAMBI (NP_036474.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:100 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:MCF7, Mouse lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 21-152 of human BAMBI (NP_036474.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VLLT KGEI RCYC DAAH CVAT GYMC KSEL SACF SRLL DPQN SNSP LTHG CLDS LAST TDIC QAKQ ARNH SGTT IPTL ECCH EDMC NYRG LHDV LSPP RGEA SGQG NRYQ HDGS RNLI TKVQ ELTS SKEL WFRA
Gene ID:25805
Uniprot:Q13145
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:29kDa
Observed MW:53kDa
Synonyms:BAMBI, NMA
Background:This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis.
UniProt Protein Function:BAMBI: Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Inhibitor

Chromosomal Location of Human Ortholog: 10p12.3-p11.2

Cellular Component: cytoplasm; integral to membrane; plasma membrane

Molecular Function:frizzled binding; punt binding

Biological Process: regulation of cell shape; cell migration; positive regulation of protein binding; positive regulation of transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; positive regulation of cell proliferation; negative regulation of transforming growth factor beta receptor signaling pathway

NCBI Summary:This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis. [provided by RefSeq, Jul 2008]
UniProt Code:Q13145
NCBI GenInfo Identifier:2498645
NCBI Gene ID:25805
NCBI Accession:Q13145.1
UniProt Related Accession:Q13145
Molecular Weight:260
NCBI Full Name:BMP and activin membrane-bound inhibitor homolog
NCBI Synonym Full Names:BMP and activin membrane-bound inhibitor
NCBI Official Symbol:BAMBI  
NCBI Official Synonym Symbols:NMA  
NCBI Protein Information:BMP and activin membrane-bound inhibitor homolog; non-metastatic gene A protein; putative transmembrane protein NMA
UniProt Protein Name:BMP and activin membrane-bound inhibitor homolog
UniProt Synonym Protein Names:Non-metastatic gene A protein; Putative transmembrane protein NMA
Protein Family:BMP and activin membrane-bound inhibitor
UniProt Gene Name:BAMBI  
UniProt Entry Name:BAMBI_HUMAN
Anti-BAMBI Antibody (CAB13589)Western blot analysis of extracts of various cell lines, using BAMBI antibody (CAB13589) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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