Cell Biology Antibodies 7
Anti-BAG4 Antibody (CAB17052)
- SKU:
- CAB17052
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Antibody Name: | Anti-BAG4 Antibody |
Antibody SKU: | CAB17052 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB IHC |
Reactivity: | Human, Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human BAG4 (NP_001191807.1). |
Application: | WB IHC |
Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
Reactivity: | Human, Mouse, Rat |
Positive Samples: |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human BAG4 (NP_001191807.1). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | MSAL RRSG YGPS DGPS YGRY YGPG GGDV PVHP PPPL YPLR PEPP QPPI SWRV RGGG PAET TWLG EGGG GDGY YPSG GAWP EPGR AGGS HQSL NSYT NGAY |
Gene ID: | 9530 |
Uniprot: | O95429 |
Cellular Location: | |
Calculated MW: | 45kDa/49kDa |
Observed MW: | Refer to figures |
Synonyms: | BAG4, BAG-4, SODD |
Background: | The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. |
UniProt Protein Function: | BAG4: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Prevents constitutive TNFRSF1A signaling. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Apoptosis Chromosomal Location of Human Ortholog: 8p11.23 Cellular Component: cytosol; nucleus; plasma membrane Molecular Function:adenyl-nucleotide exchange factor activity; protein binding; receptor signaling protein activity; ubiquitin protein ligase binding Biological Process: negative regulation of apoptosis; protein folding; tumor necrosis factor-mediated signaling pathway |
NCBI Summary: | The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011] |
UniProt Code: | O95429 |
NCBI GenInfo Identifier: | 12643661 |
NCBI Gene ID: | 9530 |
NCBI Accession: | O95429.1 |
UniProt Secondary Accession: | O95429,O95818, B4E217, |
UniProt Related Accession: | O95429 |
Molecular Weight: | 45,410 Da |
NCBI Full Name: | BAG family molecular chaperone regulator 4 |
NCBI Synonym Full Names: | BCL2 associated athanogene 4 |
NCBI Official Symbol: | BAG4 |
NCBI Official Synonym Symbols: | SODD; BAG-4 |
NCBI Protein Information: | BAG family molecular chaperone regulator 4 |
UniProt Protein Name: | BAG family molecular chaperone regulator 4 |
UniProt Synonym Protein Names: | Bcl-2-associated athanogene 4; Silencer of death domains |
Protein Family: | BAG family molecular chaperone regulator |
UniProt Gene Name: | BAG4 |
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