Cell Death Antibodies 2
Anti-BAG3 Antibody (CAB4720)
- SKU:
- CAB4720
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- BAG-3
- Synonyms:
- BIS
- Synonyms:
- CAIR-1
- Synonyms:
- MFM6
- Research Area:
- Cell Death
Description
| Product Name: | BAG3 Rabbit mAb |
| Product Code: | CAB4720 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | BAG-3, BIS, CAIR-1, MFM6 |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human BAG3 |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, K-562, U-251MG |
| Immunogen: | A synthesized peptide derived from human BAG3 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 9531 |
| Uniprot: | O95817 |
| Calculated MW: | 80kDa |
| Observed MW: | 74KDa |
| UniProt Protein Function: | BAG3: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity. Defects in BAG3 are the cause of myopathy myofibrillar type 6 (MFM6). A neuromuscular disorder that results in early-onset, severe, progressive, diffuse muscle weakness associated with cardiomyopathy, severe respiratory insufficiency during adolescence, and a rigid spine in some patients. At ultrastructural level, muscle fibers display structural alterations consisting of replacement of the normal myofibrillar markings by small, dense granules, or larger hyaline masses, or amorphous material. Defects in BAG3 are the cause of cardiomyopathy dilated type 1HH (CMD1HH). CMD1HH is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. |
| UniProt Protein Details: | Protein type:Apoptosis Chromosomal Location of Human Ortholog: 10q26.11 Cellular Component: cell-cell adherens junction; cytoplasm; cytosol; plasma membrane Molecular Function:adenyl-nucleotide exchange factor activity; protein binding Biological Process: induction of apoptosis via death domain receptors Disease: Cardiomyopathy, Dilated, 1hh; Myopathy, Myofibrillar, 6 |
| NCBI Summary: | BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O95817 |
| NCBI GenInfo Identifier: | 12643665 |
| NCBI Gene ID: | 9531 |
| NCBI Accession: | O95817.3 |
| UniProt Secondary Accession: | O95817,Q3B763, Q9NT20, Q9P120, A8K5L8, |
| UniProt Related Accession: | O95817 |
| Molecular Weight: | 61,595 Da |
| NCBI Full Name: | BAG family molecular chaperone regulator 3 |
| NCBI Synonym Full Names: | BCL2 associated athanogene 3 |
| NCBI Official Symbol: | BAG3 |
| NCBI Official Synonym Symbols: | BIS; MFM6; BAG-3; CAIR-1 |
| NCBI Protein Information: | BAG family molecular chaperone regulator 3 |
| UniProt Protein Name: | BAG family molecular chaperone regulator 3 |
| UniProt Synonym Protein Names: | Bcl-2-associated athanogene 3; Bcl-2-binding protein Bis; Docking protein CAIR-1 |
| Protein Family: | BAG family molecular chaperone regulator |
| UniProt Gene Name: | BAG3 |
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