Cell Biology Antibodies 5

Anti-BACE2 Antibody (CAB14864)

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SKU:
CAB14864
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-BACE2 Antibody
Antibody SKU:CAB14864
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 240-470 of human BACE2 (NP_036237.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:DU145
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 240-470 of human BACE2 (NP_036237.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:AGSG TNGG SLVL GGIE PSLY KGDI WYTP IKEE WYYQ IEIL KLEI GGQS LNLD CREY NADK AIVD SGTT LLRL PQKV FDAV VEAV ARAS LIPE FSDG FWTG SQLA CWTN SETP WSYF PKIS IYLR DENS SRSF RITI LPQL YIQP MMGA GLNY ECYR FGIS PSTN ALVI GATV MEGF YVIF DRAQ KRVG FAAS PCAE IAGA AVSE ISGP FSTE DVAS NCVP AQSL SEPI LWI
Gene ID:25825
Uniprot:Q9Y5Z0
Cellular Location:Cell surface, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane, Single-pass type I membrane protein
Calculated MW:42kDa/46kDa/48kDa/50kDa/56kDa
Observed MW:56kDa
Synonyms:BACE2, AEPLC, ALP56, ASP1, ASP21, BAE2, CDA13, CEAP1, DRAP
Background:This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:BACE2: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C- terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Belongs to the peptidase A1 family. 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 3.4.23.45; Protease; Membrane protein, integral

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: Golgi apparatus; cell surface; endoplasmic reticulum; integral to membrane; endosome

Molecular Function:aspartic-type endopeptidase activity

Biological Process: negative regulation of amyloid precursor protein biosynthetic process; membrane protein ectodomain proteolysis; peptide hormone processing; proteolysis

NCBI Summary:This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniProt Code:Q9Y5Z0
NCBI GenInfo Identifier:6685260
NCBI Gene ID:25825
NCBI Accession:Q9Y5Z0.1
UniProt Secondary Accession:Q9Y5Z0,Q5DIH8, Q8N2D4, Q9H2V8, Q9NZL1, Q9NZL2, Q9UJT6 A8K7P1,
UniProt Related Accession:Q9Y5Z0
Molecular Weight:518
NCBI Full Name:Beta-secretase 2
NCBI Synonym Full Names:beta-site APP-cleaving enzyme 2
NCBI Official Symbol:BACE2  
NCBI Official Synonym Symbols:ASP1; BAE2; DRAP; AEPLC; ALP56; ASP21; CDA13; CEAP1  
NCBI Protein Information:beta-secretase 2; memapsin-1; theta-secretase; aspartyl protease 1; 56 kDa aspartic-like protease; Down syndrome region aspartic protease; transmembrane aspartic proteinase Asp1; membrane-associated aspartic protease 1; beta-site amyloid beta A4 precursor protein-cleaving enzyme 2
UniProt Protein Name:Beta-secretase 2
UniProt Synonym Protein Names:Aspartic-like protease 56 kDa; Aspartyl protease 1; ASP1; Asp 1; Beta-site amyloid precursor protein cleaving enzyme 2; Beta-site APP cleaving enzyme 2; Down region aspartic protease; DRAP; Memapsin-1; Membrane-associated aspartic protease 1; Theta-secretase
Protein Family:Beta-secretase
UniProt Gene Name:BACE2  
UniProt Entry Name:BACE2_HUMAN
Anti-BACE2 Antibody (CAB14864)Western blot analysis of extracts of DU145 cells, using BACE2 antibody (CAB14864) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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