Cell Biology Antibodies 16
Anti-BACE1 Antibody (CAB11533)
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- SKU:
- CAB11533
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-BACE1 Antibody |
| Antibody SKU: | CAB11533 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human BACE1 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SH-SY5Y, Mouse brain, Rat brain |
| Immunogen: | A synthesized peptide derived from human BACE1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 23621 |
| Uniprot: | P56817 |
| Cellular Location: | |
| Calculated MW: | 70kDa |
| Observed MW: | 70KDa |
 | Western blot - BACE1 Rabbit mAb (CAB11533) |
| Synonyms: | ASP2, BACE, HSPC104 |
| Background: | This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. [provided by RefSeq, Nov 2015] |
| UniProt Protein Function: | BACE: an integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Cleaves APP at the amino terminus of the A-beta peptide sequence, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated carboxy-terminal fragment which is later release by gamma-secretase. Four splice-variant isoforms have been described. |
| UniProt Protein Details: | Protein type:EC 3.4.23.46; Membrane protein, integral; Protease Chromosomal Location of Human Ortholog: 11q23.2-q23.3 Cellular Component: endoplasmic reticulum lumen; endosome; endosome membrane; Golgi apparatus; integral to plasma membrane; late endosome; multivesicular body; plasma membrane; trans-Golgi network Molecular Function:aspartic-type endopeptidase activity; beta-amyloid binding; beta-aspartyl-peptidase activity; enzyme binding; peptidase activity; protein binding Biological Process: beta-amyloid metabolic process; cellular protein metabolic process; membrane protein ectodomain proteolysis; protein catabolic process; proteolysis |
| NCBI Summary: | This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. [provided by RefSeq, Nov 2015] |
| UniProt Code: | P56817 |
| NCBI GenInfo Identifier: | 296434407 |
| NCBI Gene ID: | 23621 |
| NCBI Accession: | P56817.2 |
| UniProt Secondary Accession: | P56817,Q9BYB9, Q9BYC0, Q9BYC1, Q9UJT5, Q9ULS1, A0M8W7 B0YIU9, E9PE65, H7BXJ9, |
| UniProt Related Accession: | P56817 |
| Molecular Weight: | 42,107 Da |
| NCBI Full Name: | Beta-secretase 1 |
| NCBI Synonym Full Names: | beta-secretase 1 |
| NCBI Official Symbol: | BACE1 |
| NCBI Official Synonym Symbols: | ASP2; BACE; HSPC104 |
| NCBI Protein Information: | beta-secretase 1 |
| UniProt Protein Name: | Beta-secretase 1 |
| UniProt Synonym Protein Names: | Aspartyl protease 2; ASP2; Asp 2; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; Memapsin-2; Membrane-associated aspartic protease 2 |
| Protein Family: | Beta-secretase |
| UniProt Gene Name: | BACE1 |
| UniProt Entry Name: | BACE1_HUMAN |
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