Immunology Antibodies 1
Anti-B7-H4/VTCN1 Antibody (CAB10412)
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- SKU:
- CAB10412
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-B7-H4/VTCN1 Antibody |
| Antibody SKU: | CAB10412 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-260 of human B7-H4/VTCN1 (NP_078902.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | MCF7, SKOV3, HeLa, 293T, B cells, Mouse uterus, Rat thymus |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-260 of human B7-H4/VTCN1 (NP_078902.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | RTAV FADQ VIVG NASL RLKN VQLT DAGT YKCY IITS KGKG NANL EYKT GAFS MPEV NVDY NASS ETLR CEAP RWFP QPTV VWAS QVDQ GANF SEVS NTSF ELNS ENVT MKVV SVLY NVTI NNTY SCMI ENDI AKAT GDIK VTES EIKR RSHL QLLN SKAS L |
| Gene ID: | 79679 |
| Uniprot: | Q7Z7D3 |
| Cellular Location: | Cell membrane, Single-pass type I membrane protein |
| Calculated MW: | 9kDa/18kDa/20kDa/30kDa |
| Observed MW: | 36kDa |
| Synonyms: | VTCN1, B7-H4, B7H4, B7S1, B7X, B7h.5, PRO1291, VCTN1 |
| Background: | This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | VTCN1: Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor- associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. Belongs to the immunoglobulin superfamily. BTN/MOG family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 1p13.1-p12 |
| NCBI Summary: | This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
| UniProt Code: | Q7Z7D3 |
| NCBI GenInfo Identifier: | 74759262 |
| NCBI Gene ID: | 79679 |
| NCBI Accession: | Q7Z7D3.1 |
| UniProt Secondary Accession: | Q7Z7D3,Q0GN76, Q45VN0, Q5WPZ3, Q6P097, Q9H6B2, |
| UniProt Related Accession: | Q7Z7D3 |
| Molecular Weight: | |
| NCBI Full Name: | V-set domain-containing T-cell activation inhibitor 1 |
| NCBI Synonym Full Names: | V-set domain containing T-cell activation inhibitor 1 |
| NCBI Official Symbol: | VTCN1 |
| NCBI Official Synonym Symbols: | B7X; B7H4; B7S1; B7-H4; B7h.5; VCTN1; PRO1291 |
| NCBI Protein Information: | V-set domain-containing T-cell activation inhibitor 1 |
| UniProt Protein Name: | V-set domain-containing T-cell activation inhibitor 1 |
| UniProt Synonym Protein Names: | B7 homolog 4; B7-H4; B7h.5; Immune costimulatory protein B7-H4; Protein B7S1; T-cell costimulatory molecule B7x |
| UniProt Gene Name: | VTCN1 |
 | Western blot analysis of extracts of various cell lines, using B7-H4/VTCN1 antibody (CAB10412) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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