Cell Biology Antibodies 14
Anti-B4GALT6 Antibody (CAB17047)
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- SKU:
- CAB17047
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-B4GALT6 Antibody |
| Antibody SKU: | CAB17047 |
| Antibody Size: | 20uL, 50 uL |
| Application: | WB |
| Reactivity: | Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-140 of human B4GALT6 (NP_004766.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-140 of human B4GALT6 (NP_004766.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GIML RENV KTIG HMIR LYTN KNST LNGT DYPE GNNS SDYL VQTT TYLP ENFT YSPY LPCP EKLP YMRG FLNV NVSE VSFD EIHQ LFSK DLD |
| Gene ID: | 9331 |
| Uniprot: | Q9UBX8 |
| Cellular Location: | |
| Calculated MW: | 40kDa/44kDa |
| Observed MW: | Refer to figures |
| Synonyms: | B4GALT6, B4Gal-T6, beta4Gal-T6, beta-1 |
| Background: | This gene is one of seven beta-1, 4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1, 4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene is a lactosylceramide synthase important for glycolipid biosynthesis. |
| UniProt Protein Function: | B4GALT6: Required for the biosynthesis of glycosphingolipids. Belongs to the glycosyltransferase 7 family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; EC 2.4.1.274; Lipid Metabolism - sphingolipid; Transferase Chromosomal Location of Human Ortholog: 18q11 Cellular Component: Golgi membrane Molecular Function:beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity; galactosyltransferase activity Biological Process: keratan sulfate biosynthetic process |
| NCBI Summary: | This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene is a lactosylceramide synthase important for glycolipid biosynthesis. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UBX8 |
| NCBI GenInfo Identifier: | 13123991 |
| NCBI Gene ID: | 9331 |
| NCBI Accession: | Q9UBX8.1 |
| UniProt Secondary Accession: | Q9UBX8,O60514, Q6NT09, |
| UniProt Related Accession: | Q9UBX8 |
| Molecular Weight: | 40,127 Da |
| NCBI Full Name: | Beta-1,4-galactosyltransferase 6 |
| NCBI Synonym Full Names: | beta-1,4-galactosyltransferase 6 |
| NCBI Official Symbol: | B4GALT6 |
| NCBI Official Synonym Symbols: | B4Gal-T6; beta4Gal-T6 |
| NCBI Protein Information: | beta-1,4-galactosyltransferase 6 |
| UniProt Protein Name: | Beta-1,4-galactosyltransferase 6 |
| UniProt Synonym Protein Names: | Lactosylceramide synthase; LacCer synthase; UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase |
| Protein Family: | Beta-1,4-galactosyltransferase |
| UniProt Gene Name: | B4GALT6 |
| UniProt Entry Name: | B4GT6_HUMAN |
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