Cell Biology Antibodies 13

Anti-B4GALT3 Antibody (CAB17572)

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SKU:
CAB17572
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-B4GALT3 Antibody
Antibody SKU:CAB17572
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 40-150 of human B4GALT3 (NP_003770.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:100 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse heart, Rat spleen, Rat kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 40-150 of human B4GALT3 (NP_003770.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:RDQG PTFD YSHP RDVY SNLS HLPG APGG PPAP QGLP YCPE RSPL LVGP VSVS FSPV PSLA EIVE RNPR VEPG GRYR PAGC EPRS RTAI IVPH RARE HHLR LLLY HLHP FLQ
Gene ID:8703
Uniprot:O60512
Cellular Location:
Calculated MW:15kDa/43kDa
Observed MW:44kDa
Anti-B4GALT3 Antibody (CAB17572)Western blot - B4GALT3 Polyclonal Antibody (CAB17572)
Synonyms:B4GALT3, beta4Gal-T3, beta-1
Background:This gene is one of seven beta-1, 4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1, 4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene encodes an enzyme that may be mainly involved in the synthesis of the first N-acetyllactosamine unit of poly-N-acetyllactosamine chains. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2010]
UniProt Protein Function:B4GALT3: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Belongs to the glycosyltransferase 7 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 2.4.1.38; EC 2.4.1.90; Glycan Metabolism - N-glycan biosynthesis; Glycan Metabolism - glycosphingolipid biosynthesis - lacto and neolacto series; Glycan Metabolism - keratan sulfate biosynthesis; Membrane protein, integral; Transferase

Chromosomal Location of Human Ortholog: 1q23.3

Cellular Component: cytosol; Golgi apparatus; Golgi membrane

Molecular Function:beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity; galactosyltransferase activity

Biological Process: keratan sulfate biosynthetic process

NCBI Summary:This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene encodes an enzyme that may be mainly involved in the synthesis of the first N-acetyllactosamine unit of poly-N-acetyllactosamine chains. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2010]
UniProt Code:O60512
NCBI GenInfo Identifier:68053339
NCBI Gene ID:8703
NCBI Accession:O60512.2
UniProt Secondary Accession:O60512,O60910, Q9BPZ4, Q9H8T2, D3DVG3,
UniProt Related Accession:O60512
Molecular Weight:44kDa
NCBI Full Name:Beta-1,4-galactosyltransferase 3
NCBI Synonym Full Names:beta-1,4-galactosyltransferase 3
NCBI Official Symbol:B4GALT3  
NCBI Official Synonym Symbols:beta4Gal-T3  
NCBI Protein Information:beta-1,4-galactosyltransferase 3
UniProt Protein Name:Beta-1,4-galactosyltransferase 3
UniProt Synonym Protein Names:UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 3; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 3Including the following 3 domains:N-acetyllactosamine synthase (EC:2.4.1.90)Alternative name(s):Nal synthase
Protein Family:Beta-1,4-galactosyltransferase
UniProt Gene Name:B4GALT3  
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