Metabolism Antibodies 3
Anti-B3GALTL Antibody (CAB9014)
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- SKU:
- CAB9014
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-B3GALTL Antibody |
| Antibody SKU: | CAB9014 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 259-498 of human B3GALTL (NP_919299.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | U-251MG, HeLa, SKOV3, HepG2, MCF7 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 259-498 of human B3GALTL (NP_919299.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LCRK PVKK KDIF VAVK TCKK FHGD RIPI VKQT WESQ ASLI EYYS DYTE NSIP TVDL GIPN TDRG HCGK TFAI LERF LNRS QDKT AWLV IVDD DTLI SISR LQHL LSCY DSGE PVFL GERY GYGL GTGG YSYI TGGG GMVF SREA VRRL LASK CRCY SNDA PDDM VLGM CFSG LGIP VTHS PLFH QARP VDYP KDYL SHQV PISF HKHW NIDP VKVY FTWL APSD EDKA RQET QKGF REEL |
| Gene ID: | 145173 |
| Uniprot: | Q6Y288 |
| Cellular Location: | Endoplasmic reticulum membrane, Single-pass type II membrane protein |
| Calculated MW: | 56kDa |
| Observed MW: | 56kDa |
| Synonyms: | B3GLCT, B3GALTL, B3GTL, B3Glc-T, Gal-T, beta3Glc-T |
| Background: | The protein encoded by this gene is a beta-1, 3-glucosyltransferase that transfers glucose to O-linked fucosylglycans on thrombospondin type-1 repeats (TSRs) of several proteins. The encoded protein is a type II membrane protein. Defects in this gene are a cause of Peters-plus syndrome (PPS). |
| UniProt Protein Function: | B3GALTL: O-fucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan. Defects in B3GALTL are the cause of Peters-plus syndrome (PpS). PpS is an autosomal recessive disorder characterized by anterior eye-chamber abnormalities, disproportionate short stature, developmental delay, characteristic craniofacial features, cleft lip and/or palate. Belongs to the glycosyltransferase 31 family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; EC 2.4.1.-; Transferase Chromosomal Location of Human Ortholog: 13q12.3 Cellular Component: endoplasmic reticulum membrane; integral to membrane Molecular Function:transferase activity, transferring glycosyl groups Biological Process: cellular protein metabolic process; fucose metabolic process; post-translational protein modification; protein amino acid O-linked glycosylation Disease: Peters-plus Syndrome |
| NCBI Summary: | The protein encoded by this gene is a beta-1,3-glucosyltransferase that transfers glucose to O-linked fucosylglycans on thrombospondin type-1 repeats (TSRs) of several proteins. The encoded protein is a type II membrane protein. Defects in this gene are a cause of Peters-plus syndrome (PPS).[provided by RefSeq, Mar 2009] |
| UniProt Code: | Q6Y288 |
| NCBI GenInfo Identifier: | 116243011 |
| NCBI Gene ID: | 145173 |
| NCBI Accession: | Q6Y288.2 |
| UniProt Secondary Accession: | Q6Y288,Q5W0H2, Q6NUI3, A8K5F8, |
| UniProt Related Accession: | Q6Y288 |
| Molecular Weight: | 56,564 Da |
| NCBI Full Name: | Beta-1,3-glucosyltransferase |
| NCBI Synonym Full Names: | beta 3-glucosyltransferase |
| NCBI Official Symbol: | B3GLCT |
| NCBI Official Synonym Symbols: | B3GTL; Gal-T; B3GALTL; B3Glc-T; beta3Glc-T |
| NCBI Protein Information: | beta-1,3-glucosyltransferase |
| UniProt Protein Name: | Beta-1,3-glucosyltransferase |
| UniProt Synonym Protein Names: | Beta 3-glucosyltransferase |
| UniProt Gene Name: | B3GLCT |
| UniProt Entry Name: | B3GLT_HUMAN |
 | Western blot analysis of extracts of various cell lines, using B3GALTL antibody (CAB9014) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 20s. |
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