Metabolism Antibodies 3

Anti-B3GALTL Antibody (CAB9014)

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SKU:
CAB9014
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Metabolism

Description

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Antibody Name:Anti-B3GALTL Antibody
Antibody SKU:CAB9014
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 259-498 of human B3GALTL (NP_919299.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:U-251MG, HeLa, SKOV3, HepG2, MCF7
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 259-498 of human B3GALTL (NP_919299.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LCRK PVKK KDIF VAVK TCKK FHGD RIPI VKQT WESQ ASLI EYYS DYTE NSIP TVDL GIPN TDRG HCGK TFAI LERF LNRS QDKT AWLV IVDD DTLI SISR LQHL LSCY DSGE PVFL GERY GYGL GTGG YSYI TGGG GMVF SREA VRRL LASK CRCY SNDA PDDM VLGM CFSG LGIP VTHS PLFH QARP VDYP KDYL SHQV PISF HKHW NIDP VKVY FTWL APSD EDKA RQET QKGF REEL
Gene ID:145173
Uniprot:Q6Y288
Cellular Location:Endoplasmic reticulum membrane, Single-pass type II membrane protein
Calculated MW:56kDa
Observed MW:56kDa
Synonyms:B3GLCT, B3GALTL, B3GTL, B3Glc-T, Gal-T, beta3Glc-T
Background:The protein encoded by this gene is a beta-1, 3-glucosyltransferase that transfers glucose to O-linked fucosylglycans on thrombospondin type-1 repeats (TSRs) of several proteins. The encoded protein is a type II membrane protein. Defects in this gene are a cause of Peters-plus syndrome (PPS).
UniProt Protein Function:B3GALTL: O-fucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan. Defects in B3GALTL are the cause of Peters-plus syndrome (PpS). PpS is an autosomal recessive disorder characterized by anterior eye-chamber abnormalities, disproportionate short stature, developmental delay, characteristic craniofacial features, cleft lip and/or palate. Belongs to the glycosyltransferase 31 family.
UniProt Protein Details:

Protein type:Membrane protein, integral; EC 2.4.1.-; Transferase

Chromosomal Location of Human Ortholog: 13q12.3

Cellular Component: endoplasmic reticulum membrane; integral to membrane

Molecular Function:transferase activity, transferring glycosyl groups

Biological Process: cellular protein metabolic process; fucose metabolic process; post-translational protein modification; protein amino acid O-linked glycosylation

Disease: Peters-plus Syndrome

NCBI Summary:The protein encoded by this gene is a beta-1,3-glucosyltransferase that transfers glucose to O-linked fucosylglycans on thrombospondin type-1 repeats (TSRs) of several proteins. The encoded protein is a type II membrane protein. Defects in this gene are a cause of Peters-plus syndrome (PPS).[provided by RefSeq, Mar 2009]
UniProt Code:Q6Y288
NCBI GenInfo Identifier:116243011
NCBI Gene ID:145173
NCBI Accession:Q6Y288.2
UniProt Secondary Accession:Q6Y288,Q5W0H2, Q6NUI3, A8K5F8,
UniProt Related Accession:Q6Y288
Molecular Weight:56,564 Da
NCBI Full Name:Beta-1,3-glucosyltransferase
NCBI Synonym Full Names:beta 3-glucosyltransferase
NCBI Official Symbol:B3GLCT  
NCBI Official Synonym Symbols:B3GTL; Gal-T; B3GALTL; B3Glc-T; beta3Glc-T  
NCBI Protein Information:beta-1,3-glucosyltransferase
UniProt Protein Name:Beta-1,3-glucosyltransferase
UniProt Synonym Protein Names:Beta 3-glucosyltransferase
UniProt Gene Name:B3GLCT  
UniProt Entry Name:B3GLT_HUMAN
Anti-B3GALTL Polyclonal Antibody (CAB9014)Western blot analysis of extracts of various cell lines, using B3GALTL antibody (CAB9014) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 20s.
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