Description
| Product Name: | AZIN1 Rabbit pAb |
| Product Code: | CAB4747 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | AZIN1, AZI, AZI1, AZIA1, OAZI, OAZIN, ODC1L |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 289-448 of human AZIN1 (NP_056962.2). |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, Mouse thymus, Rat thymus |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 289-448 of human AZIN1 (NP_056962.2). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AKKV VEND KFPS GVEK TGSD EPAF MYYM NDGV YGSF ASKL SEDL NTIP EVHK KYKE DEPL FTSS LWGP SCDE LDQI VESC LLPE LNVG DWLI FDNM GADS FHEP SAFN DFQR PAIY YMMS FSDW YEMQ DAGI TSDS MMKN FFFV PSCI QLSQ EDSF SAEA |
| Gene ID: | 51582 |
| Uniprot: | O14977 |
| Cellular Location: | Nucleus |
| Calculated MW: | 49kDa |
| Observed MW: | 49kDa |
| UniProt Protein Function: | AZIN1: Regulates cellular polyamine homeostasis. Inhibits antizyme-dependent ornithine decarboxylase degradation by binding to antizyme. Belongs to the Orn/Lys/Arg decarboxylase class-II family. ODC antizyme inhibitor subfamily. |
| UniProt Protein Details: | Protein type:Inhibitor Chromosomal Location of Human Ortholog: 8q22.3 Cellular Component: nucleus; cytosol Molecular Function:enzyme inhibitor activity; ornithine decarboxylase activator activity; catalytic activity Biological Process: positive regulation of catalytic activity; polyamine biosynthetic process; negative regulation of catalytic activity; regulation of amino acid metabolic process; negative regulation of protein catabolic process |
| NCBI Summary: | The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. RNA editing of this gene, predominantly in the liver tissue, has been linked to the progression of hepatocellular carcinoma. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2014] |
| UniProt Code: | O14977 |
| NCBI GenInfo Identifier: | 33860187 |
| NCBI Gene ID: | 51582 |
| NCBI Accession: | O14977.2 |
| UniProt Secondary Accession: | O14977,Q6IBQ7, Q96D20, A6NCD5, |
| UniProt Related Accession: | O14977 |
| Molecular Weight: | 49,535 Da |
| NCBI Full Name: | Antizyme inhibitor 1 |
| NCBI Synonym Full Names: | antizyme inhibitor 1 |
| NCBI Official Symbol: | AZIN1 |
| NCBI Official Synonym Symbols: | AZI; OAZI; AZIA1; OAZIN; ODC1L |
| NCBI Protein Information: | antizyme inhibitor 1; ornithine decarboxylase antizyme inhibitor |
| UniProt Protein Name: | Antizyme inhibitor 1 |
| UniProt Synonym Protein Names: | Ornithine decarboxylase antizyme inhibitor |
| Protein Family: | Antizyme inhibitor |
| UniProt Gene Name: | AZIN1 |
| UniProt Entry Name: | AZIN1_HUMAN |
