Cell Biology Antibodies 12
Anti-AVPR1A Antibody (CAB8400)
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- SKU:
- CAB8400
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-AVPR1A Antibody |
| Antibody SKU: | CAB8400 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 349-418 of human AVPR1A (NP_000697.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, A-549, Mouse liver, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 349-418 of human AVPR1A (NP_000697.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MFFS GHLL QDCV QSFP CCQN MKEK FNKE DTDS MSRR QTFY SNNR SPTN STGM WKDS PKSS KSIK FIPV ST |
| Gene ID: | 552 |
| Uniprot: | P37288 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 46kDa |
| Observed MW: | 60kDa |
| Synonyms: | AVPR1A, AVPR V1a, AVPR1, V1aR, AVPRV1a |
| Background: | The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1B, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor mediates cell contraction and proliferation, platelet aggregation, release of coagulation factor and glycogenolysis. |
| UniProt Protein Function: | AVPR1A: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1; Membrane protein, integral Chromosomal Location of Human Ortholog: 12q14-q15 Cellular Component: endosome; integral to plasma membrane; plasma membrane Molecular Function:peptide binding; protein binding; protein kinase C binding Biological Process: blood circulation; cellular response to hormone stimulus; generation of precursor metabolites and energy; maternal behavior; phospholipase C activation; positive regulation of vasoconstriction; regulation of systemic arterial blood pressure by vasopressin |
| NCBI Summary: | The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1B, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor mediates cell contraction and proliferation, platelet aggregation, release of coagulation factor and glycogenolysis. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P37288 |
| NCBI GenInfo Identifier: | 586197 |
| NCBI Gene ID: | 552 |
| NCBI Accession: | P37288.1 |
| UniProt Related Accession: | P37288 |
| Molecular Weight: | 46,800 Da |
| NCBI Full Name: | Vasopressin V1a receptor |
| NCBI Synonym Full Names: | arginine vasopressin receptor 1A |
| NCBI Official Symbol: | AVPR1A |
| NCBI Official Synonym Symbols: | V1aR; AVPR1; AVPR V1a |
| NCBI Protein Information: | vasopressin V1a receptor |
| UniProt Protein Name: | Vasopressin V1a receptor |
| UniProt Synonym Protein Names: | AVPR V1a; Antidiuretic hormone receptor 1a; Vascular/hepatic-type arginine vasopressin receptor |
| Protein Family: | Vasopressin V1a receptor |
| UniProt Gene Name: | AVPR1A |
| UniProt Entry Name: | V1AR_HUMAN |
 | Western blot analysis of extracts of various cell lines, using AVPR1A antibody (CAB8400) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s. |
 | Immunofluorescence analysis of C6 cells using AVPR1A Rabbit pAb (CAB8400) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of NIH/3T3 cells using AVPR1A Rabbit pAb (CAB8400) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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