Cell Biology Antibodies 12

Anti-AVPR1A Antibody (CAB8400)

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SKU:
CAB8400
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-AVPR1A Antibody
Antibody SKU:CAB8400
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 349-418 of human AVPR1A (NP_000697.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, A-549, Mouse liver, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 349-418 of human AVPR1A (NP_000697.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MFFS GHLL QDCV QSFP CCQN MKEK FNKE DTDS MSRR QTFY SNNR SPTN STGM WKDS PKSS KSIK FIPV ST
Gene ID:552
Uniprot:P37288
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:46kDa
Observed MW:60kDa
Synonyms:AVPR1A, AVPR V1a, AVPR1, V1aR, AVPRV1a
Background:The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1B, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor mediates cell contraction and proliferation, platelet aggregation, release of coagulation factor and glycogenolysis.
UniProt Protein Function:AVPR1A: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12q14-q15

Cellular Component: endosome; integral to plasma membrane; plasma membrane

Molecular Function:peptide binding; protein binding; protein kinase C binding

Biological Process: blood circulation; cellular response to hormone stimulus; generation of precursor metabolites and energy; maternal behavior; phospholipase C activation; positive regulation of vasoconstriction; regulation of systemic arterial blood pressure by vasopressin

NCBI Summary:The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1B, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor mediates cell contraction and proliferation, platelet aggregation, release of coagulation factor and glycogenolysis. [provided by RefSeq, Jul 2008]
UniProt Code:P37288
NCBI GenInfo Identifier:586197
NCBI Gene ID:552
NCBI Accession:P37288.1
UniProt Related Accession:P37288
Molecular Weight:46,800 Da
NCBI Full Name:Vasopressin V1a receptor
NCBI Synonym Full Names:arginine vasopressin receptor 1A
NCBI Official Symbol:AVPR1A  
NCBI Official Synonym Symbols:V1aR; AVPR1; AVPR V1a  
NCBI Protein Information:vasopressin V1a receptor
UniProt Protein Name:Vasopressin V1a receptor
UniProt Synonym Protein Names:AVPR V1a; Antidiuretic hormone receptor 1a; Vascular/hepatic-type arginine vasopressin receptor
Protein Family:Vasopressin V1a receptor
UniProt Gene Name:AVPR1A  
UniProt Entry Name:V1AR_HUMAN
Anti-AVPR1A Polyclonal Antibody (CAB8400)Western blot analysis of extracts of various cell lines, using AVPR1A antibody (CAB8400) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s.
Anti-AVPR1A Polyclonal Antibody (CAB8400)Immunofluorescence analysis of C6 cells using AVPR1A Rabbit pAb (CAB8400) at dilution of 1:100. Blue: DAPI for nuclear staining.
Anti-AVPR1A Polyclonal Antibody (CAB8400)Immunofluorescence analysis of NIH/3T3 cells using AVPR1A Rabbit pAb (CAB8400) at dilution of 1:100. Blue: DAPI for nuclear staining.
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