Cell Biology Antibodies 6
Anti-AVIL Antibody (CAB15785)
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- SKU:
- CAB15785
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-AVIL Antibody |
| Antibody SKU: | CAB15785 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 470-819 of human AVIL (NP_006567.3). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HT-29, Mouse uterus, Mouse brain, Rat uterus, Rat testis, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 470-819 of human AVIL (NP_006567.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AAVQ VRVR MGTE PRHF MAIF KGKL VIFE GGTS RKGN AEPD PPVR LFQI HGND KSNT KAVE VPAF ASSL NSND VFLL RTQA EHYL WYGK GSSG DERA MAKE LASL LCDG SENT VAEG QEPA EFWD LLGG KTPY ANDK RLQQ EILD VQSR LFEC SNKT GQFV VTEI TDFT QDDL NPTD VMLL DTWD QVFL WIGA EANA TEKE SALA TAQQ YLHT HPSG RDPD TPIL IIKQ GFEP PIFT GWFL AWDP NIWS AGKT YEQL KEEL GDAA AIMR ITAD MKNA TLSL NSND SEPK YYPI AVLL KNQN QELP EDVN PAKK ENYL SEQD FVSV FGIT RGQF AALP GWKQ LQMK KEKG LF |
| Gene ID: | 10677 |
| Uniprot: | O75366 |
| Cellular Location: | Cell projection, Cytoplasm, axon, cytoskeleton |
| Calculated MW: | 91kDa/92kDa |
| Observed MW: | 105kDa, 115kDa |
| Synonyms: | AVIL, ADVIL, DOC6, p92, advillin |
| Background: | The protein encoded by this gene is a member of the gelsolin/villin family of actin regulatory proteins. This protein has structural similarity to villin. It binds actin and may play a role in the development of neuronal cells that form ganglia. |
| UniProt Protein Function: | AVIL: Ca(2+)-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis. Belongs to the villin/gelsolin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cytoskeletal Chromosomal Location of Human Ortholog: 12q14.1 Cellular Component: actin cytoskeleton; cell projection; neuron projection Molecular Function:actin binding Biological Process: nervous system development |
| NCBI Summary: | The protein encoded by this gene is a member of the gelsolin/villin family of actin regulatory proteins. This protein has structural similarity to villin. It binds actin and may play a role in the development of neuronal cells that form ganglia. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O75366 |
| NCBI GenInfo Identifier: | 313104246 |
| NCBI Gene ID: | 10677 |
| NCBI Accession: | O75366.3 |
| UniProt Secondary Accession: | O75366,Q2NKM9, B2RAU7, |
| UniProt Related Accession: | O75366 |
| Molecular Weight: | 91,163 Da |
| NCBI Full Name: | Advillin |
| NCBI Synonym Full Names: | advillin |
| NCBI Official Symbol: | AVIL |
| NCBI Official Synonym Symbols: | p92; DOC6; ADVIL |
| NCBI Protein Information: | advillin |
| UniProt Protein Name: | Advillin |
| UniProt Synonym Protein Names: | p92 |
| Protein Family: | Advillin |
| UniProt Gene Name: | AVIL |
| UniProt Entry Name: | AVIL_HUMAN |
 | Western blot analysis of extracts of various cell lines, using AVIL antibody (CAB15785) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunofluorescence analysis of L929 cells using AVIL antibody (CAB15785) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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