Cell Cycle Antibodies 2
Anti-AURKC Antibody (CAB7930)
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- SKU:
- CAB7930
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
| Antibody Name: | Anti-AURKC Antibody |
| Antibody SKU: | CAB7930 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human AURKC |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, 293T, SW620, BT-474, Mouse testis, Mouse ovary, Mouse pancreas, Rat brain |
| Immunogen: | A synthetic peptide of human AURKC |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 6795 |
| Uniprot: | Q9UQB9 |
| Cellular Location: | Chromosome, Cytoplasm, Nucleus, centromere, cytoskeleton, spindle |
| Calculated MW: | 32kDa/33kDa/35kDa |
| Observed MW: | 36kDa |
| Synonyms: | AURKC, AIE2, AIK3, ARK3, AurC, HEL-S-90, SPGF5, STK13, aurora-C |
| Background: | This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | AurC: a member of the AUR family of kinases. May play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. Localized to centrosome from anaphase to cytokinesis. Two splice-variant isoforms have been described. |
| UniProt Protein Details: | Protein type:Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, Other; EC 2.7.11.1; Other group; AUR family Chromosomal Location of Human Ortholog: 19q13.43 Cellular Component: condensed chromosome; condensed nuclear chromosome, pericentric region; midbody; spindle; spindle microtubule; spindle midzone; spindle pole centrosome Molecular Function:histone serine kinase activity; protein kinase activity; protein serine/threonine/tyrosine kinase activity Biological Process: attachment of spindle microtubules to kinetochore; histone modification; positive regulation of cytokinesis; protein amino acid phosphorylation; spindle midzone assembly involved in mitosis Disease: Spermatogenic Failure 5 |
| NCBI Summary: | This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UQB9 |
| NCBI GenInfo Identifier: | 27805738 |
| NCBI Gene ID: | 6795 |
| NCBI Accession: | Q9UQB9.1 |
| UniProt Secondary Accession: | Q9UQB9,O60681, O75442, Q6AZY8, Q6DLZ0, Q9UPK5, |
| UniProt Related Accession: | Q9UQB9 |
| Molecular Weight: | 33,672 Da |
| NCBI Full Name: | Aurora kinase C |
| NCBI Synonym Full Names: | aurora kinase C |
| NCBI Official Symbol: | AURKC |
| NCBI Official Synonym Symbols: | AIE2; AIK3; ARK3; AurC; SPGF5; STK13; HEL-S-90; aurora-C |
| NCBI Protein Information: | aurora kinase C |
| UniProt Protein Name: | Aurora kinase C |
| UniProt Synonym Protein Names: | Aurora 3; Aurora/IPL1-related kinase 3; ARK-3; Aurora-related kinase 3; Aurora/IPL1/Eg2 protein 2; Serine/threonine-protein kinase 13; Serine/threonine-protein kinase aurora-C |
| Protein Family: | Aurora kinase |
| UniProt Gene Name: | AURKC |
| UniProt Entry Name: | AURKC_HUMAN |
 | Western blot analysis of extracts of various cell lines, using AURKC antibody (CAB7930) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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