Cell Cycle Antibodies 2

Anti-AURKC Antibody (CAB7930)

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SKU:
CAB7930
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Cycle

Description

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Antibody Name:Anti-AURKC Antibody
Antibody SKU:CAB7930
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide of human AURKC
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, 293T, SW620, BT-474, Mouse testis, Mouse ovary, Mouse pancreas, Rat brain
Immunogen:A synthetic peptide of human AURKC
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:6795
Uniprot:Q9UQB9
Cellular Location:Chromosome, Cytoplasm, Nucleus, centromere, cytoskeleton, spindle
Calculated MW:32kDa/33kDa/35kDa
Observed MW:36kDa
Synonyms:AURKC, AIE2, AIK3, ARK3, AurC, HEL-S-90, SPGF5, STK13, aurora-C
Background:This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:AurC: a member of the AUR family of kinases. May play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. Localized to centrosome from anaphase to cytokinesis. Two splice-variant isoforms have been described.
UniProt Protein Details:

Protein type:Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, Other; EC 2.7.11.1; Other group; AUR family

Chromosomal Location of Human Ortholog: 19q13.43

Cellular Component: condensed chromosome; condensed nuclear chromosome, pericentric region; midbody; spindle; spindle microtubule; spindle midzone; spindle pole centrosome

Molecular Function:histone serine kinase activity; protein kinase activity; protein serine/threonine/tyrosine kinase activity

Biological Process: attachment of spindle microtubules to kinetochore; histone modification; positive regulation of cytokinesis; protein amino acid phosphorylation; spindle midzone assembly involved in mitosis

Disease: Spermatogenic Failure 5

NCBI Summary:This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UQB9
NCBI GenInfo Identifier:27805738
NCBI Gene ID:6795
NCBI Accession:Q9UQB9.1
UniProt Secondary Accession:Q9UQB9,O60681, O75442, Q6AZY8, Q6DLZ0, Q9UPK5,
UniProt Related Accession:Q9UQB9
Molecular Weight:33,672 Da
NCBI Full Name:Aurora kinase C
NCBI Synonym Full Names:aurora kinase C
NCBI Official Symbol:AURKC  
NCBI Official Synonym Symbols:AIE2; AIK3; ARK3; AurC; SPGF5; STK13; HEL-S-90; aurora-C  
NCBI Protein Information:aurora kinase C
UniProt Protein Name:Aurora kinase C
UniProt Synonym Protein Names:Aurora 3; Aurora/IPL1-related kinase 3; ARK-3; Aurora-related kinase 3; Aurora/IPL1/Eg2 protein 2; Serine/threonine-protein kinase 13; Serine/threonine-protein kinase aurora-C
Protein Family:Aurora kinase
UniProt Gene Name:AURKC  
UniProt Entry Name:AURKC_HUMAN
Anti-AURKC Antibody (CAB7930)Western blot analysis of extracts of various cell lines, using AURKC antibody (CAB7930) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
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