Metabolism Antibodies 3

Anti-ATPB Antibody (CAB11214)

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SKU:
CAB11214
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Metabolism

Description

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Antibody Name:Anti-ATPB Antibody
Antibody SKU:CAB11214
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human ATPB
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, PC-12, HepG2, Jurkat, Mouse liver, Mouse brain, Rat liver, Rat brain
Immunogen:A synthesized peptide derived from human ATPB
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:506
Uniprot:P06576
Cellular Location:Mitochondrion, Mitochondrion inner membrane
Calculated MW:50kDa
Observed MW:57KDa
Anti-ATPB AntibodyWestern blot - ATPB Rabbit mAb (CAB11214)
Synonyms:ATPMB, ATPSB, HEL-S-271
Background:This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the beta subunit of the catalytic core. [provided by RefSeq, Jul 2008]
UniProt Protein Function:ATP5B: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Belongs to the ATPase alpha/beta chains family.
UniProt Protein Details:

Protein type:EC 3.6.3.14; Hydrolase; Mitochondrial; Energy Metabolism - oxidative phosphorylation

Chromosomal Location of Human Ortholog: 12q13.13

Cellular Component: cell surface; membrane; mitochondrial matrix; mitochondrial membrane; mitochondrial proton-transporting ATP synthase complex; mitochondrion; nucleus; plasma membrane

Molecular Function:ATPase activity; hydrogen ion transporting ATPase activity, rotational mechanism; MHC class I protein binding; protein binding; transmembrane transporter activity

Biological Process: angiogenesis; ATP biosynthetic process; mitochondrial ATP synthesis coupled proton transport; mitochondrion organization and biogenesis; osteoblast differentiation; proton transport; regulation of intracellular pH

NCBI Summary:This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the beta subunit of the catalytic core. [provided by RefSeq, Jul 2008]
UniProt Code:P06576
NCBI GenInfo Identifier:114549
NCBI Gene ID:506
NCBI Accession:P06576.3
UniProt Secondary Accession:P06576,Q14283, A8K4X0,
UniProt Related Accession:P06576
Molecular Weight:56,560 Da
NCBI Full Name:ATP synthase subunit beta, mitochondrial
NCBI Synonym Full Names:ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
NCBI Official Symbol:ATP5B  
NCBI Official Synonym Symbols:ATPMB; ATPSB; HEL-S-271  
NCBI Protein Information:ATP synthase subunit beta, mitochondrial
UniProt Protein Name:ATP synthase subunit beta, mitochondrial
UniProt Gene Name:ATP5B  
UniProt Entry Name:ATPB_HUMAN
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