Epigenetics & Nuclear Signaling Antibodies 4
Anti-ATPase WRNIP1 Antibody (CAB9170)
(No reviews yet)
Write a Review
- SKU:
- CAB9170
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-ATPase WRNIP1 Antibody |
| Antibody SKU: | CAB9170 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 401-640 of human WRNIP1 (NP_569079.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HeLa |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 401-640 of human WRNIP1 (NP_569079.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | DKAV DTLA YLSD GDAR AGLN GLQL AVLA RLSS RKMF CKKS GQSY SPSR VLIT ENDV KEGL QRSH ILYD RAGE EHYN CISA LHKS MRGS DQNA SLYW LARM LEGG EDPL YVAR RLVR FASE DIGL ADPS ALTQ AVAA YQGC HFIG MPEC EVLL AQCV VYFA RAPK SIEV YSAY NNVK ACLR NHQG PLPP VPLH LRNA PTRL MKDL GYGK GYKY NPMY SEPV DQEY LPEE LRGV DFFK QRRC |
| Gene ID: | 56897 |
| Uniprot: | Q96S55 |
| Cellular Location: | Nucleus |
| Calculated MW: | 31kDa/49kDa/69kDa/72kDa |
| Observed MW: | 72kDa |
| Synonyms: | WRNIP1, WHIP, bA420G6.2 |
| Background: | Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene. |
| UniProt Protein Function: | WRNIP1: a modulator for initiation or restart of DNA polymerase delta-mediated DNA synthesis. Its ATPase activity may sense DNA ends and regulate the extent of polymerase stimulation. |
| UniProt Protein Details: | Protein type:Helicase; EC 3.6.1.3 Chromosomal Location of Human Ortholog: 6p25.2 Cellular Component: membrane; nuclear chromosome, telomeric region; nucleus; perinuclear region of cytoplasm Molecular Function:ATPase activity; identical protein binding; protein binding Biological Process: DNA synthesis during DNA repair; regulation of DNA replication initiation |
| NCBI Summary: | Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene. [provided by RefSeq, Jul 2012] |
| UniProt Code: | Q96S55 |
| NCBI GenInfo Identifier: | 73622085 |
| NCBI Gene ID: | 56897 |
| NCBI Accession: | Q96S55.2 |
| UniProt Secondary Accession: | Q96S55,Q53EP6, Q59ET8, Q5W0E2, Q5W0E4, Q8WV26, Q9H681 Q9NRJ6, B2RDB0, |
| UniProt Related Accession: | Q96S55 |
| Molecular Weight: | 31,339 Da |
| NCBI Full Name: | ATPase WRNIP1 |
| NCBI Synonym Full Names: | Werner helicase interacting protein 1 |
| NCBI Official Symbol: | WRNIP1 |
| NCBI Official Synonym Symbols: | WHIP; bA420G6.2 |
| NCBI Protein Information: | ATPase WRNIP1 |
| UniProt Protein Name: | ATPase WRNIP1 |
| UniProt Synonym Protein Names: | Werner helicase-interacting protein 1 |
| UniProt Gene Name: | WRNIP1 |
| UniProt Entry Name: | WRIP1_HUMAN |
View AllClose
Related Products
Na /K -ATPase Polyclonal Antibody
Na /K -ATPase Polyclonal AntibodyThe product page for this antibody is being prepared. If you have a question please don't hesitate to get in touch!