Cell Biology Antibodies 18

Anti-ATP6V1C1 Antibody (CAB18253)

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SKU:
CAB18253
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-ATP6V1C1 Antibody
Antibody SKU:CAB18253
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide of human ATP6V1C1.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:U-251MG, 293T, Mouse kidney
Immunogen:A synthetic peptide of human ATP6V1C1.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:528
Uniprot:P21283
Cellular Location:
Calculated MW:43kDa
Observed MW:43kDa
Anti-ATP6V1C1 Antibody (CAB18253)Western blot - ATP6V1C1 Polyclonal Antibody (CAB18253)
Synonyms:ATP6V1C1, ATP6C, ATP6D, VATC, Vma5
Background:This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D.
UniProt Protein Function:ATP6V1C1: Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Belongs to the V-ATPase C subunit family.
UniProt Protein Details:

Protein type:Hydrolase; Membrane protein, integral; Energy Metabolism - oxidative phosphorylation; Transporter; EC 3.6.3.14

Chromosomal Location of Human Ortholog: 8q22.3

Cellular Component: apical part of cell; lysosomal membrane; plasma membrane; cytoplasmic vesicle; proton-transporting two-sector ATPase complex; cytosol

Molecular Function:hydrogen-exporting ATPase activity, phosphorylative mechanism; protein binding; transporter activity; hydrogen ion transporting ATPase activity, rotational mechanism

Biological Process: interaction with host; proton transport; cellular iron ion homeostasis; ATP hydrolysis coupled proton transport; insulin receptor signaling pathway; transferrin transport; transmembrane transport

NCBI Summary:This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D. [provided by RefSeq, Jul 2008]
UniProt Code:P21283
NCBI GenInfo Identifier:401329
NCBI Gene ID:528
NCBI Accession:P21283.4
UniProt Related Accession:P21283
Molecular Weight:
NCBI Full Name:V-type proton ATPase subunit C 1
NCBI Synonym Full Names:ATPase H+ transporting V1 subunit C1
NCBI Official Symbol:ATP6V1C1  
NCBI Official Synonym Symbols:VATC; Vma5; ATP6C; ATP6D  
NCBI Protein Information:V-type proton ATPase subunit C 1
UniProt Protein Name:V-type proton ATPase subunit C 1
UniProt Synonym Protein Names:Vacuolar proton pump subunit C 1
UniProt Gene Name:ATP6V1C1  
UniProt Entry Name:VATC1_HUMAN
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