Cell Biology Antibodies 4
Anti-ATP2A3 Antibody (CAB14232)
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- SKU:
- CAB14232
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ATP2A3 Antibody |
| Antibody SKU: | CAB14232 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 360-600 of human ATP2A3 (NP_005164.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Raji, HT-29, Jurkat, Mouse kidney, Mouse lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 360-600 of human ATP2A3 (NP_005164.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QMSV CRMF VVAE ADAG SCLL HEFT ISGT TYTP EGEV RQGD QPVR CGQF DGLV ELAT ICAL CNDS ALDY NEAK GVYE KVGE ATET ALTC LVEK MNVF DTDL QALS RVER AGAC NTVI KQLM RKEF TLEF SRDR KSMS VYCT PTRP HPTG QGSK MFVK GAPE SVIE RCSS VRVG SRTA PLTP TSRE QILA KIRD WGSG SDTL RCLA LATR DAPP RKED MELD DCSK FVQY ETDL TFVG CVGM L |
| Gene ID: | 489 |
| Uniprot: | Q93084 |
| Cellular Location: | Endoplasmic reticulum membrane, Multi-pass membrane protein, Nucleus membrane, Sarcoplasmic reticulum membrane |
| Calculated MW: | 109kDa/112kDa/113kDa/114kDa |
| Observed MW: | 114kDa |
| Synonyms: | ATP2A3, SERCA3 |
| Background: | This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| UniProt Protein Function: | ATP2A3: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. 7 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Hydrolase; Endoplasmic reticulum; Transporter; Transporter, ion channel; EC 3.6.3.8; Membrane protein, integral Chromosomal Location of Human Ortholog: 17p13.3 Cellular Component: endoplasmic reticulum membrane; sarcoplasmic reticulum membrane; nuclear membrane; sarcoplasmic reticulum; endoplasmic reticulum; integral to membrane Molecular Function:calcium-transporting ATPase activity; metal ion binding; ATP binding Biological Process: transport; metabolic process; calcium ion transport; blood coagulation; transmembrane transport |
| NCBI Summary: | This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q93084 |
| NCBI GenInfo Identifier: | 19864659 |
| NCBI Gene ID: | 489 |
| NCBI Accession: | Q93084.2 |
| UniProt Related Accession: | Q93084 |
| Molecular Weight: | |
| NCBI Full Name: | Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 |
| NCBI Synonym Full Names: | ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 |
| NCBI Official Symbol: | ATP2A3 |
| NCBI Official Synonym Symbols: | SERCA3 |
| NCBI Protein Information: | sarcoplasmic/endoplasmic reticulum calcium ATPase 3 |
| UniProt Protein Name: | Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 |
| UniProt Synonym Protein Names: | Calcium pump 3 |
| Protein Family: | Sarcoplasmic/endoplasmic reticulum calcium ATPase |
| UniProt Gene Name: | ATP2A3 |
| UniProt Entry Name: | AT2A3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ATP2A3 antibody (CAB14232) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded human breast cancer using ATP2A3 antibody (CAB14232) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human lung using ATP2A3 antibody (CAB14232) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human uterine cancer using ATP2A3 antibody (CAB14232) at dilution of 1:100 (40x lens). |
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