Cell Biology Antibodies 17

Anti-ATP1B1 Antibody (CAB5113)

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SKU:
CAB5113
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-ATP1B1 Antibody
Antibody SKU:CAB5113
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human ATP1B1
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:U2OS, Mouse liver, Mouse brain, Rat brain
Immunogen:A synthesized peptide derived from human ATP1B1
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:481
Uniprot:P05026
Cellular Location:
Calculated MW:40-50kDa
Observed MW:50KDa
Synonyms:ATP1B
Background:The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known. [provided by RefSeq, Mar 2010]
UniProt Protein Function:ATP1B1: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Transporter; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q24

Cellular Component: apical plasma membrane; basolateral plasma membrane; caveola; intracellular; membrane; myelin sheath; plasma membrane; sarcolemma; sodium:potassium-exchanging ATPase complex

Molecular Function:ATP binding; ATPase activator activity; ATPase activity; ATPase binding; drug binding; potassium ion binding; protein binding; protein C-terminus binding; sodium ion binding; sodium:potassium-exchanging ATPase activity

Biological Process: ATP metabolic process; blood coagulation; cardiac muscle contraction; cell adhesion; cellular calcium ion homeostasis; cellular potassium ion homeostasis; cellular sodium ion homeostasis; establishment and/or maintenance of transmembrane electrochemical gradient; leukocyte migration; positive regulation of ATPase activity; positive regulation of defense response to virus by host; potassium ion import; protein stabilization; regulation of gene expression; response to hypoxia; transmembrane transport

Disease: Hypertension, Essential

NCBI Summary:The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known. [provided by RefSeq, Mar 2010]
UniProt Code:P05026
NCBI GenInfo Identifier:114392
NCBI Gene ID:481
NCBI Accession:P05026.1
UniProt Secondary Accession:P05026,Q5TGZ3,
UniProt Related Accession:P05026
Molecular Weight:34,893 Da
NCBI Full Name:Sodium/potassium-transporting ATPase subunit beta-1
NCBI Synonym Full Names:ATPase Na+/K+ transporting subunit beta 1
NCBI Official Symbol:ATP1B1  
NCBI Official Synonym Symbols:ATP1B  
NCBI Protein Information:sodium/potassium-transporting ATPase subunit beta-1
UniProt Protein Name:Sodium/potassium-transporting ATPase subunit beta-1
UniProt Synonym Protein Names:Sodium/potassium-dependent ATPase subunit beta-1
UniProt Gene Name:ATP1B1  
UniProt Entry Name:AT1B1_HUMAN
Anti-ATP1B1 Antibody (CAB5113)Western blot - ATP1B1 Rabbit mAb (CAB5113)
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