Epigenetics & Nuclear Signaling Antibodies 4

Anti-ATMIN Antibody (CAB7272)

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SKU:
CAB7272
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-ATMIN Antibody
Antibody SKU:CAB7272
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 160-360 of human ATMIN (NP_056066.2).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:MCF7, Mouse testis, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 160-360 of human ATMIN (NP_056066.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:HAEK KHKC SKCS NSYG TEWD LKRH AEDC GKTF RCTC GCPY ASRT ALQS HIYR TGHE IPAE HRDP PSKK RKME NCAQ NQKL SNKT IESL NNQP IPRP DTQE LEAS EIKL EPSF EDSC GSNT DKQT LTTP PRYP QKLL LPKP KVAL VKLP VMQF SVMP VFVP TADS SAQP VVLG VDQG SATG AVHL MPLS VGTL ILGL DSEA C
Gene ID:23300
Uniprot:O43313
Cellular Location:Nucleus
Calculated MW:72kDa/88kDa
Observed MW:68-88kDa
Synonyms:ATMIN, ASCIZ, ZNF822
Background:
UniProt Protein Function:ATMIN: Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:DNA repair, damage; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 16q23.2

Cellular Component: nucleus

Molecular Function:dynein binding; protein binding; metal ion binding

Biological Process: transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; response to DNA damage stimulus

UniProt Code:O43313
NCBI GenInfo Identifier:215273936
NCBI Gene ID:23300
NCBI Accession:O43313.2
UniProt Secondary Accession:O43313,Q68DC9, A8K4H8,
UniProt Related Accession:O43313
Molecular Weight:823
NCBI Full Name:ATM interactor
NCBI Synonym Full Names:ATM interactor
NCBI Official Symbol:ATMIN  
NCBI Official Synonym Symbols:ASCIZ; ZNF822  
NCBI Protein Information:ATM interactor; ATM INteracting protein; zinc finger protein 822; ATM/ATR-Substrate Chk2-Interacting Zn++-finger protein; ATM/ATR-substrate CHK2-interacting zinc finger protein; ATM/ATR-substrate CHEK2-interacting zinc finger protein
UniProt Protein Name:ATM interactor
UniProt Synonym Protein Names:ATM/ATR-substrate CHK2-interacting zinc finger protein; ASCIZ; Zinc finger protein 822
Protein Family:ATM interactor
UniProt Gene Name:ATMIN  
UniProt Entry Name:ATMIN_HUMAN
Anti-ATMIN Antibody (CAB7272)Western blot analysis of extracts of various cell lines, using ATMIN antibody (CAB7272) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s.
Anti-ATMIN Antibody (CAB7272)Immunofluorescence analysis of MCF-7 cells using ATMIN antibody (CAB7272).
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