Metabolism Antibodies 2

Anti-ATGL/PNPLA2 Antibody (CAB6245)

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SKU:
CAB6245
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism

Description

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Antibody Name:Anti-ATGL/PNPLA2 Antibody
Antibody SKU:CAB6245
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 265-504 of human PNPLA2 (NP_065109.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:A-549, HepG2, THP-1, A673
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 265-504 of human PNPLA2 (NP_065109.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:PPAR PHGP EDKD QAVE SAQA EDYS QLPG EDHI LEHL PARL NEAL LEAC VEPT DLLT TLSN MLPV RLAT AMMV PYTL PLES ALSF TIRL LEWL PDVP EDIR WMKE QTGS ICQY LVMR AKRK LGRH LPSR LPEQ VELR RVQS LPSV PLSC AAYR EALP GWMR NNLS LGDA LAKW EECQ RQLL LGLF CTNV AFPP EALR MRAP ADPA PAPA DPAS PQHQ LAGP APLL STPA PEAR PVIG ALGL
Gene ID:57104
Uniprot:Q96AD5
Cellular Location:Cell membrane, Lipid droplet, Single-pass type II membrane protein
Calculated MW:19kDa/55kDa
Observed MW:55kDa
Synonyms:PNPLA2, 1110001C14Rik, ATGL, FP17548, PEDF-R, TTS-2.2, TTS2, iPLA2zeta
Background:This gene encodes an enzyme which catalyzes the first step in the hydrolysis of triglycerides in adipose tissue. Mutations in this gene are associated with neutral lipid storage disease with myopathy.
UniProt Protein Function:Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (PubMed:15550674). Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes (PubMed:16239926). May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion.
NCBI Summary:This gene encodes an enzyme which catalyzes the first step in the hydrolysis of triglycerides in adipose tissue. Mutations in this gene are associated with neutral lipid storage disease with myopathy. [provided by RefSeq, Jul 2010]
UniProt Code:Q96AD5
NCBI GenInfo Identifier:74731110
NCBI Gene ID:57104
NCBI Accession:Q96AD5.1
UniProt Secondary Accession:Q96AD5,O60643, Q5EFF5, Q6XYE5, Q96ET6, Q9NQ61, Q9NQ62
UniProt Related Accession:Q96AD5
Molecular Weight:19,875 Da
NCBI Full Name:Patatin-like phospholipase domain-containing protein 2
NCBI Synonym Full Names:patatin like phospholipase domain containing 2
NCBI Official Symbol:PNPLA2  
NCBI Official Synonym Symbols:ATGL; TTS2; PEDF-R; FP17548; TTS-2.2; iPLA2zeta; 1110001C14Rik  
NCBI Protein Information:patatin-like phospholipase domain-containing protein 2
UniProt Protein Name:Patatin-like phospholipase domain-containing protein 2
UniProt Synonym Protein Names:Adipose triglyceride lipase; Calcium-independent phospholipase A2; Desnutrin; IPLA2-zeta; Pigment epithelium-derived factor; TTS2.2; Transport-secretion protein 2; TTS2
UniProt Gene Name:PNPLA2  
Anti-ATGL/PNPLA2 Antibody (CAB6245)Western blot analysis of extracts of various cell lines, using ATGL/PNPLA2 antibody (CAB6245) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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