UniProt Protein Function: | Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (PubMed:15550674). Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes (PubMed:16239926). May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion. |
NCBI Summary: | This gene encodes an enzyme which catalyzes the first step in the hydrolysis of triglycerides in adipose tissue. Mutations in this gene are associated with neutral lipid storage disease with myopathy. [provided by RefSeq, Jul 2010] |
UniProt Code: | Q96AD5 |
NCBI GenInfo Identifier: | 74731110 |
NCBI Gene ID: | 57104 |
NCBI Accession: | Q96AD5.1 |
UniProt Secondary Accession: | Q96AD5,O60643, Q5EFF5, Q6XYE5, Q96ET6, Q9NQ61, Q9NQ62 |
UniProt Related Accession: | Q96AD5 |
Molecular Weight: | 19,875 Da |
NCBI Full Name: | Patatin-like phospholipase domain-containing protein 2 |
NCBI Synonym Full Names: | patatin like phospholipase domain containing 2 |
NCBI Official Symbol: | PNPLA2 |
NCBI Official Synonym Symbols: | ATGL; TTS2; PEDF-R; FP17548; TTS-2.2; iPLA2zeta; 1110001C14Rik |
NCBI Protein Information: | patatin-like phospholipase domain-containing protein 2 |
UniProt Protein Name: | Patatin-like phospholipase domain-containing protein 2 |
UniProt Synonym Protein Names: | Adipose triglyceride lipase; Calcium-independent phospholipase A2; Desnutrin; IPLA2-zeta; Pigment epithelium-derived factor; TTS2.2; Transport-secretion protein 2; TTS2 |
UniProt Gene Name: | PNPLA2 |