Autophagy Antibodies

Anti-ATG4C Antibody (CAB15200)

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SKU:
CAB15200
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Autophagy

Description

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Antibody Name:Anti-ATG4C Antibody
Antibody SKU:CAB15200
Antibody Size:20uL, 50uL, 100uL
Application:IF
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human ATG4C (NP_116241.2).
Application:IF
Recommended Dilution:IF 1:50 - 1:200
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human ATG4C (NP_116241.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MEAT GTDE VDKL KTKF ISAW NNMK YSWV LKTK TYFS RNSP VLLL GKCY HFKY EDED KTLP AESG CTIE DHVI AGNV EEFR KDFI SRIW LTYR EEFP QIEG SALT TDCG WGCT LRTG QMLL AQGL ILHF LGRA WTWP DALN IENS DSES WTSH TVKK FTAS FEAS LSGE REFK TPTI SLKE TIGK YSDD HEMR NEVY HRKI
Gene ID:84938
Uniprot:Q96DT6
Cellular Location:Cytoplasm
Calculated MW:52kDa
Observed MW:
Synonyms:ATG4C, APG4-C, APG4C, AUTL1, AUTL3
Background:Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized.
UniProt Protein Function:ATG4C: Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Highly expressed in skeletal muscle, heart, liver and testis. Inhibited by N-ethylmaleimide. Belongs to the peptidase C54 family.
UniProt Protein Details:

Protein type:Autophagy; Protease; Ubiquitin conjugating system; EC 3.4.22.-

Chromosomal Location of Human Ortholog: 1p31.3

Cellular Component: cytoplasm; cytosol; extracellular region

Molecular Function:cysteine-type endopeptidase activity; peptidase activity

Biological Process: autophagic vacuole formation; autophagy; C-terminal protein lipidation; mitochondrion degradation; protein delipidation; protein processing; protein targeting to membrane; proteolysis

NCBI Summary:Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized. [provided by RefSeq, Jul 2008]
UniProt Code:Q96DT6
NCBI GenInfo Identifier:61211867
NCBI Gene ID:84938
NCBI Accession:Q96DT6.1
UniProt Secondary Accession:Q96DT6,Q96K04, A6NLR8, D3DQ58,
UniProt Related Accession:Q96DT6
Molecular Weight:52,497 Da
NCBI Full Name:Cysteine protease ATG4C
NCBI Synonym Full Names:autophagy related 4C cysteine peptidase
NCBI Official Symbol:ATG4C  
NCBI Official Synonym Symbols:APG4C; AUTL1; AUTL3; APG4-C  
NCBI Protein Information:cysteine protease ATG4C
UniProt Protein Name:Cysteine protease ATG4C
UniProt Synonym Protein Names:AUT-like 3 cysteine endopeptidase; Autophagin-3; Autophagy-related cysteine endopeptidase 3; Autophagy-related protein 4 homolog C
Protein Family:Cysteine protease
UniProt Gene Name:ATG4C  
UniProt Entry Name:ATG4C_HUMAN
Anti-ATG4C Antibody (CAB15200)Immunofluorescence analysis of U2OS cells using ATG4C antibody (CAB15200) at dilution of 1:100. Blue: DAPI for nuclear staining.
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