Autophagy Antibodies

Anti-ATG4B Antibody (CAB5059)

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SKU:
CAB5059
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
APG4B
Synonyms:
AUTL1
Research Area:
Autophagy

Description

Product Name:ATG4B Rabbit mAb
Product Code:CAB5059
Size:20uL, 50uL, 100uL
Synonyms:APG4B, AUTL1
Applications:WB, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human ATG4B
Applications:WB, IF
Recommended Dilutions:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, RD, Jurkat, Mouse testis, Mouse brain, Rat lung, Rat brain
Immunogen:A synthesized peptide derived from human ATG4B
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:23192
Uniprot:Q9Y4P1
Cellular Location:Cytoplasm
Calculated MW:44kDa
Observed MW:48KDa
UniProt Protein Function:ATG4B: Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Mainly expressed in the skeletal muscle, followed by brain, heart, liver and pancreas. Inhibited by N-ethylmaleimide. Belongs to the peptidase C54 family. 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 3.4.22.-; Autophagy; Protease; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 2q37.3

Cellular Component: cytoplasm; cytosol

Molecular Function:cysteine-type endopeptidase activity; cysteine-type peptidase activity; endopeptidase activity; protein binding

Biological Process: autophagic vacuole formation; autophagy; C-terminal protein lipidation; macroautophagy; mitochondrion degradation; protein delipidation; protein processing; protein targeting to membrane; proteolysis

NCBI Summary:Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
UniProt Code:Q9Y4P1
NCBI GenInfo Identifier:296434400
NCBI Gene ID:23192
NCBI Accession:Q9Y4P1.2
UniProt Secondary Accession:Q9Y4P1,Q53NU4, Q6ZUV8, Q8WYM9, Q96K07, Q96K96, Q96SZ1 Q9Y2F2, B7WNK2,
UniProt Related Accession:Q9Y4P1
Molecular Weight:42,622 Da
NCBI Full Name:Cysteine protease ATG4B
NCBI Synonym Full Names:autophagy related 4B cysteine peptidase
NCBI Official Symbol:ATG4B  
NCBI Official Synonym Symbols:APG4B; AUTL1  
NCBI Protein Information:cysteine protease ATG4B
UniProt Protein Name:Cysteine protease ATG4B
UniProt Synonym Protein Names:AUT-like 1 cysteine endopeptidase; Autophagin-1; Autophagy-related cysteine endopeptidase 1; Autophagy-related protein 4 homolog B; hAPG4B
Protein Family:Cysteine protease
UniProt Gene Name:ATG4B  
UniProt Entry Name:ATG4B_HUMAN
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