Autophagy Antibodies
Anti-ATG4B Antibody (CAB5059)
- SKU:
- CAB5059
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- APG4B
- Synonyms:
- AUTL1
- Research Area:
- Autophagy
Description
| Product Name: | ATG4B Rabbit mAb |
| Product Code: | CAB5059 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | APG4B, AUTL1 |
| Applications: | WB, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human ATG4B |
| Applications: | WB, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, RD, Jurkat, Mouse testis, Mouse brain, Rat lung, Rat brain |
| Immunogen: | A synthesized peptide derived from human ATG4B |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 23192 |
| Uniprot: | Q9Y4P1 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 44kDa |
| Observed MW: | 48KDa |
| UniProt Protein Function: | ATG4B: Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Mainly expressed in the skeletal muscle, followed by brain, heart, liver and pancreas. Inhibited by N-ethylmaleimide. Belongs to the peptidase C54 family. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.4.22.-; Autophagy; Protease; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 2q37.3 Cellular Component: cytoplasm; cytosol Molecular Function:cysteine-type endopeptidase activity; cysteine-type peptidase activity; endopeptidase activity; protein binding Biological Process: autophagic vacuole formation; autophagy; C-terminal protein lipidation; macroautophagy; mitochondrion degradation; protein delipidation; protein processing; protein targeting to membrane; proteolysis |
| NCBI Summary: | Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y4P1 |
| NCBI GenInfo Identifier: | 296434400 |
| NCBI Gene ID: | 23192 |
| NCBI Accession: | Q9Y4P1.2 |
| UniProt Secondary Accession: | Q9Y4P1,Q53NU4, Q6ZUV8, Q8WYM9, Q96K07, Q96K96, Q96SZ1 Q9Y2F2, B7WNK2, |
| UniProt Related Accession: | Q9Y4P1 |
| Molecular Weight: | 42,622 Da |
| NCBI Full Name: | Cysteine protease ATG4B |
| NCBI Synonym Full Names: | autophagy related 4B cysteine peptidase |
| NCBI Official Symbol: | ATG4B |
| NCBI Official Synonym Symbols: | APG4B; AUTL1 |
| NCBI Protein Information: | cysteine protease ATG4B |
| UniProt Protein Name: | Cysteine protease ATG4B |
| UniProt Synonym Protein Names: | AUT-like 1 cysteine endopeptidase; Autophagin-1; Autophagy-related cysteine endopeptidase 1; Autophagy-related protein 4 homolog B; hAPG4B |
| Protein Family: | Cysteine protease |
| UniProt Gene Name: | ATG4B |
| UniProt Entry Name: | ATG4B_HUMAN |
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