Autophagy Antibodies

Anti-ATG16L1 Antibody (CAB14138)

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SKU:
CAB14138
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Autophagy

Description

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Antibody Name:Anti-ATG16L1 Antibody
Antibody SKU:CAB14138
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 200-300 of human ATG16L1 (NP_110430.5).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 200-300 of human ATG16L1 (NP_110430.5).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:QEAN RLNA ENEK DSRR RQAR LQKE LAEA AKEP LPVE QDDD IEVI VDET SDHT EETS PVRA ISRA ATKR LSQP AGGL LDSI TNIF GRRS VSSF PVPQ DNVD T
Gene ID:55054
Uniprot:Q676U5
Cellular Location:Cytoplasm, Peripheral membrane protein, Preautophagosomal structure membrane
Calculated MW:47kDa/49kDa/53kDa/66kDa/68kDa
Observed MW:Refer to figures
Synonyms:ATG16L1, APG16L, ATG16A, ATG16L, IBD10, WDR30
Background:The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:ATG16L1: Plays an essential role in autophagy. Homooligomer. Interacts with ATG5. Part of either the minor and major complexes respectively composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kDa) or 8 sets of ATG12-ATG5 and ATG16L1 (800 kDa). Belongs to the WD repeat ATG16 family. 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, peripheral; Adaptor/scaffold; Autophagy

Chromosomal Location of Human Ortholog: 2q37.1

Cellular Component: autophagic vacuole; axoneme; cytosol

Molecular Function:identical protein binding; protein binding; small conjugating protein ligase activity

Biological Process: autophagic vacuole formation; macroautophagy

Disease: Inflammatory Bowel Disease 10

NCBI Summary:The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2010]
UniProt Code:Q676U5
NCBI GenInfo Identifier:62510482
NCBI Gene ID:55054
NCBI Accession:Q676U5.2
UniProt Secondary Accession:Q676U5,Q6IPN1, Q6UXW4, Q6ZVZ5, Q8NCY2, Q96JV5, Q9H619 A3EXK9, A3EXL0, B6ZDH0,
UniProt Related Accession:Q676U5
Molecular Weight:49,486 Da
NCBI Full Name:Autophagy-related protein 16-1
NCBI Synonym Full Names:autophagy related 16 like 1
NCBI Official Symbol:ATG16L1  
NCBI Official Synonym Symbols:IBD10; WDR30; APG16L; ATG16A; ATG16L  
NCBI Protein Information:autophagy-related protein 16-1
UniProt Protein Name:Autophagy-related protein 16-1
UniProt Synonym Protein Names:APG16-like 1
Protein Family:Autophagy-related protein
UniProt Gene Name:ATG16L1  
UniProt Entry Name:A16L1_HUMAN
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