Autophagy Antibodies

Anti-ATG10 Antibody (CAB6848)

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SKU:
CAB6848
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Autophagy

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-ATG10 Antibody
Antibody SKU:CAB6848
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human ATG10
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:HeLa, 293T, K-562, SH-SY5Y, Mouse heart
Immunogen:A synthesized peptide derived from human ATG10
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:83734
Uniprot:Q9H0Y0
Cellular Location:Cytoplasm
Calculated MW:25kDa
Observed MW:28KDa
Synonyms:APG10, APG10L, pp12616
Background:Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A; MIM 601242), a homolog of yeast Apg8, to a membrane-bound form (Nemoto et al., 2003 [PubMed 12890687]).[supplied by OMIM, Mar 2008]
UniProt Protein Function:ATG10: E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3. Belongs to the ATG10 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 6.3.2.-; Autophagy; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 5q14.1

Cellular Component: cytosol; intracellular

Molecular Function:APG12 conjugating enzyme activity

Biological Process: autophagy; macroautophagy; positive regulation of protein modification process; protein amino acid lipidation; protein modification by small protein conjugation

NCBI Summary:Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A; MIM 601242), a homolog of yeast Apg8, to a membrane-bound form (Nemoto et al., 2003 [PubMed 12890687]).[supplied by OMIM, Mar 2008]
UniProt Code:Q9H0Y0
NCBI GenInfo Identifier:62286633
NCBI Gene ID:83734
NCBI Accession:Q9H0Y0.1
UniProt Secondary Accession:Q9H0Y0,Q6PIX1, Q9H842, B2RE09,
UniProt Related Accession:Q9H0Y0
Molecular Weight:14,217 Da
NCBI Full Name:Ubiquitin-like-conjugating enzyme ATG10
NCBI Synonym Full Names:autophagy related 10
NCBI Official Symbol:ATG10  
NCBI Official Synonym Symbols:APG10; APG10L; pp12616  
NCBI Protein Information:ubiquitin-like-conjugating enzyme ATG10
UniProt Protein Name:Ubiquitin-like-conjugating enzyme ATG10
UniProt Synonym Protein Names:Autophagy-related protein 10; APG10-like
Protein Family:Ubiquitin-like-conjugating enzyme
UniProt Gene Name:ATG10  
UniProt Entry Name:ATG10_HUMAN
Anti-ATG10 Antibody (CAB6848)Western blot - ATG10 Rabbit mAb (CAB6848)
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