Epigenetics & Nuclear Signaling Antibodies 3
Anti-ATF6B Antibody (CAB16742)
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- SKU:
- CAB16742
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-ATF6B Antibody |
| Antibody SKU: | CAB16742 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant Protein of human ATF6B |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | mouse lung, mouse brain |
| Immunogen: | Recombinant Protein of human ATF6B |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1388 |
| Uniprot: | Q99941 |
| Cellular Location: | |
| Calculated MW: | 76kDa |
| Observed MW: | 70kDa |
| Synonyms: | ATF6B, CREB-RP, CREBL1, G13 |
| Background: | The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | ATF6B: Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE. Belongs to the bZIP family. ATF subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Transcription factor Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: endoplasmic reticulum membrane; Golgi apparatus; integral to endoplasmic reticulum membrane; intracellular; nucleus Molecular Function:protein binding; transcription factor activity Biological Process: signal transduction |
| NCBI Summary: | The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] |
| UniProt Code: | Q99941 |
| NCBI GenInfo Identifier: | 20137431 |
| NCBI Gene ID: | 1388 |
| NCBI Accession: | Q99941.2 |
| UniProt Secondary Accession: | Q99941,Q13269, Q14343, Q14345, Q5SSW7, Q99635, Q99637 Q9H3V9, Q9H3W1, Q9NPL0, B0UYX6, |
| UniProt Related Accession: | Q99941 |
| Molecular Weight: | 76,412 Da |
| NCBI Full Name: | Cyclic AMP-dependent transcription factor ATF-6 beta |
| NCBI Synonym Full Names: | activating transcription factor 6 beta |
| NCBI Official Symbol: | ATF6B |
| NCBI Official Synonym Symbols: | G13; CREBL1; CREB-RP |
| NCBI Protein Information: | cyclic AMP-dependent transcription factor ATF-6 beta |
| UniProt Protein Name: | Cyclic AMP-dependent transcription factor ATF-6 beta |
| UniProt Synonym Protein Names: | Activating transcription factor 6 beta; ATF6-beta |
| Protein Family: | Cyclic AMP-dependent transcription factor |
| UniProt Gene Name: | ATF6B |
| UniProt Entry Name: | ATF6B_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ATF6B antibody (CAB16742) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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