Neuroscience
Anti-ATCAY Antibody (CAB14947)
- SKU:
- CAB14947
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Neuroscience
Description
| Antibody Name: | Anti-ATCAY Antibody |
| Antibody SKU: | CAB14947 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-105 of human ATCAY (NP_149053.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse brain, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-105 of human ATCAY (NP_149053.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGTT EATL RMEN VDVK EEWQ DEDL PRPL PEET GVEL LGSP VEDT SSPP NTLN FNGA HRKR KTLV APEI NISL DQSE GSLL SDDF LDTP DDLD INVD DIET PDET D |
| Gene ID: | 85300 |
| Uniprot: | Q86WG3 |
| Cellular Location: | Cell junction, Cell projection, Cytoplasm, Mitochondrion envelope, axon, dendrite, synapse |
| Calculated MW: | 42kDa |
| Observed MW: | 42kDa |
| Synonyms: | ATCAY, BNIP-H, CLAC, caytaxin |
| Background: | This gene encodes a neuron-restricted protein that contains a CRAL-TRIO motif common to proteins that bind small lipophilic molecules. Mutations in this gene are associated with cerebellar ataxia, Cayman type. |
| UniProt Protein Function: | ATCAY: Functions in the development of neural tissues, particularly the postnatal maturation of the cerebellar cortex. May play a role in neurotransmission through regulation of glutaminase/GLS, an enzyme responsible for the production in neurons of the glutamate neurotransmitter. Alternatively, may regulate the localization of mitochondria within axons and dendrites. Defects in ATCAY are the cause of cerebellar ataxia, cayman type (ATCAY). ATCAY is found in a population isolate on Grand Cayman Island and causes a marked psychomotor retardation and prominent nonprogressive cerebellar dysfunction including nystagmus, intention tremor, dysarthria, and wide-based ataxic gait. Hypotonia is present from early childhood. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: neuron projection; mitochondrion; axon; cytoplasm; dendrite; mitochondrial membrane; synapse; cell junction Molecular Function:protein binding; kinesin binding Biological Process: regulation of protein localization; apoptosis; transport; neurite development; mitochondrion distribution Disease: Cerebellar Ataxia, Cayman Type |
| NCBI Summary: | This gene encodes a neuron-restricted protein that contains a CRAL-TRIO motif common to proteins that bind small lipophilic molecules. Mutations in this gene are associated with cerebellar ataxia, Cayman type. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q86WG3 |
| NCBI GenInfo Identifier: | 29336043 |
| NCBI Gene ID: | 85300 |
| NCBI Accession: | NP_149053.1 |
| UniProt Secondary Accession: | Q86WG3,Q8NAQ2, Q8TAQ3, Q96HC6, Q96JF5, |
| UniProt Related Accession: | Q86WG3 |
| Molecular Weight: | 42,821 Da |
| NCBI Full Name: | caytaxin |
| NCBI Synonym Full Names: | ataxia, cerebellar, Cayman type |
| NCBI Official Symbol: | ATCAY |
| NCBI Official Synonym Symbols: | CLAC; BNIP-H |
| NCBI Protein Information: | caytaxin; Cayman ataxia; BNIP-2-homolgy; BNIP-2-homology; ataxia cayman type protein |
| UniProt Protein Name: | Caytaxin |
| UniProt Synonym Protein Names: | Ataxia cayman type protein; BNIP-2-homology; BNIP-H |
| Protein Family: | Caytaxin |
| UniProt Gene Name: | ATCAY |
| UniProt Entry Name: | ATCAY_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ATCAY antibody (CAB14947) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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