Metabolism Antibodies 1
Anti-ASMT Antibody (CAB11840)
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- SKU:
- CAB11840
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-ASMT Antibody |
| Antibody SKU: | CAB11840 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human ASMT |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human |
| Positive Samples: | 293 |
| Immunogen: | A synthetic peptide of human ASMT |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 438 |
| Uniprot: | P46597 |
| Cellular Location: | |
| Calculated MW: | 33kDa/38kDa/41kDa |
| Observed MW: | 52kDa |
| Synonyms: | ASMT, ASMTY, HIOMT, HIOMTY |
| Background: | This gene belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin, and is abundant in the pineal gland. Alternatively spliced transcript variants have been noted for this gene. |
| UniProt Protein Function: | ASMT: Produces melatonin (N-acetyl-5-methoxytryptamine) from N-acetylserotonin. Belongs to the methyltransferase superfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Amino Acid Metabolism - tryptophan; EC 2.1.1.4; Methyltransferase Chromosomal Location of Human Ortholog: Xp22.33 and Yp11.2 Cellular Component: cytosol Molecular Function:acetylserotonin O-methyltransferase activity; identical protein binding; O-methyltransferase activity; protein homodimerization activity; S-methyltransferase activity Biological Process: indolalkylamine biosynthetic process; melatonin biosynthetic process; translation |
| NCBI Summary: | This gene belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin, and is abundant in the pineal gland. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2010] |
| UniProt Code: | P46597 |
| NCBI GenInfo Identifier: | 1170276 |
| NCBI Gene ID: | 438 |
| NCBI Accession: | P46597.1 |
| UniProt Secondary Accession: | P46597,Q16598, Q5JQ72, Q5JQ73, B2RC33, |
| UniProt Related Accession: | P46597 |
| Molecular Weight: | Calculated MW: 33kDa/38kDa/41kDaObserved MW: 52kDa |
| NCBI Full Name: | Acetylserotonin O-methyltransferase |
| NCBI Synonym Full Names: | acetylserotonin O-methyltransferase |
| NCBI Official Symbol: | ASMT |
| NCBI Official Synonym Symbols: | ASMTY; HIOMT; HIOMTY |
| NCBI Protein Information: | acetylserotonin O-methyltransferase |
| UniProt Protein Name: | Acetylserotonin O-methyltransferase |
| UniProt Synonym Protein Names: | Hydroxyindole O-methyltransferase; HIOMT |
| Protein Family: | Acetylserotonin O-methyltransferase |
| UniProt Gene Name: | ASMT |
 | Western blot analysis of extracts of 293 cells, using ASMT antibody (CAB11840). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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