Cell Biology Antibodies 10

Anti-ASIP Antibody (CAB6872)

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SKU:
CAB6872
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-ASIP Antibody
Antibody SKU:CAB6872
Antibody Size:20uL, 50uL, 100uL
Application:IHC IF
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 23-132 of human ASIP (NP_001663.2).
Application:IHC IF
Recommended Dilution:IHC 1:50 - 1:100 IF 1:50 - 1:100
Reactivity:Mouse, Rat
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 23-132 of human ASIP (NP_001663.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:HLPP EEKL RDDR SLRS NSSV NLLD VPSV SIVA LNKK SKQI GRKA AEKK RSSK KEAS MKKV VRPR TPLS APCV ATRN SCKP PAPA CCDP CASC QCRF FRSA CSCR VLSL NC
Gene ID:434
Uniprot:P42127
Cellular Location:Secreted
Calculated MW:14kDa
Observed MW:
Synonyms:ASIP, AGSW, AGTI, AGTIL, ASP, SHEP9
Background:In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes.
UniProt Protein Function:ASIP: Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 20q11.2-q12

Cellular Component: extracellular space

Molecular Function:type 3 melanocortin receptor binding; type 4 melanocortin receptor binding; receptor binding

Biological Process: melanin biosynthetic process; generation of precursor metabolites and energy; regulation of molecular function, epigenetic; hormone-mediated signaling; cell-cell signaling; melanosome organization and biogenesis; adult feeding behavior; signal transduction; melanosome transport

Disease: Skin/hair/eye Pigmentation, Variation In, 9

NCBI Summary:In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes. [provided by RefSeq, Jul 2008]
UniProt Code:P42127
NCBI GenInfo Identifier:1168389
NCBI Gene ID:434
NCBI Accession:P42127.1
UniProt Secondary Accession:P42127,Q3SXL2,
UniProt Related Accession:P42127
Molecular Weight:132
NCBI Full Name:Agouti-signaling protein
NCBI Synonym Full Names:agouti signaling protein
NCBI Official Symbol:ASIP  
NCBI Official Synonym Symbols:ASP; AGSW; AGTI; AGTIL; SHEP9  
NCBI Protein Information:agouti-signaling protein; nonagouti homolog; agouti switch protein; agouti signaling protein, nonagouti homolog
UniProt Protein Name:Agouti-signaling protein
UniProt Synonym Protein Names:Agouti switch protein
Protein Family:Agouti-signaling protein
UniProt Gene Name:ASIP  
UniProt Entry Name:ASIP_HUMAN
Anti-ASIP Antibody (CAB6872)Immunohistochemistry of paraffin-embedded human prostate cancer using ASIP antibody (CAB6872) at dilution of 1:100 (40x lens).
Anti-ASIP Antibody (CAB6872)Immunohistochemistry of paraffin-embedded human gastric cancer using ASIP antibody (CAB6872) at dilution of 1:100 (40x lens).
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