Anti-ASH1L Antibody (CAB20339)

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SKU:
CAB20339
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
ASH1
Synonyms:
KMT2H
Synonyms:
MRD52
Synonyms:
ASH1L1

Description

Product Name:ASH1L Rabbit pAb
Product Code:CAB20339
Size:50uL, 100uL
Synonyms:ASH1, KMT2H, MRD52, ASH1L1
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 2074-2293 of human ASH1L (NP_060959.2).
Applications:WB
Recommended Dilutions:WB 1:1000 - 1:2000
Reactivity:Human
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 2074-2293 of human ASH1L (NP_060959.2).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:55870
Uniprot:Q9NR48
Calculated MW:332kDa
Observed MW:Refer to figures
UniProt Protein Function:ASH1L: a protein methyltransferase that specifically methylates K36 of histone H3 (H3K36me). A member of the trithorax group (trxG) of transcriptional activators that is required for proper expression of Hox genes and is preferentially expressed in haematopoietic stem cells. Widely expressed, with high levels in brain, heart and kidney. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions. Protein type: Cell adhesion; EC 2.1.1.43; Amino Acid Metabolism - lysine degradation; Methyltransferase, protein lysine; Methyltransferase Chromosomal Location of Human Ortholog: 1q22 Cellular Component: nucleoplasm; Golgi apparatus; tight junction; cytoplasm; chromosome; nucleus Molecular Function: DNA binding; zinc ion binding; histone lysine N-methyltransferase activity (H3-K4 specific); chromatin binding Biological Process: transcription from RNA polymerase II promoter; cell-cell signaling; negative regulation of MAPKKK cascade; interleukin-6 production; histone H3-K4 methylation; negative regulation of acute inflammatory response; positive regulation of transcription from RNA polymerase II promoter; negative regulation of I-kappaB kinase/NF-kappaB cascade; DNA packaging
UniProt Protein Details:
NCBI Summary:This gene encodes a member of the trithorax group of transcriptional activators. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions. [provided by RefSeq, Jul 2008]
UniProt Code:Q9NR48
NCBI GenInfo Identifier:7739725
NCBI Gene ID:55870
NCBI Accession:AAF68983.1
UniProt Secondary Accession:Q9NR48,Q59GP1, Q5T714, Q5T715, Q9P2C7
UniProt Related Accession:Q9NR48
Molecular Weight:
NCBI Full Name:ASH1
NCBI Synonym Full Names:ash1 (absent, small, or homeotic)-like (Drosophila)
NCBI Official Symbol:ASH1L  
NCBI Official Synonym Symbols:ASH1; KMT2H; ASH1L1  
NCBI Protein Information:histone-lysine N-methyltransferase ASH1L
UniProt Protein Name:Histone-lysine N-methyltransferase ASH1L
UniProt Synonym Protein Names:ASH1-like protein; huASH1; Absent small and homeotic disks protein 1 homolog; Lysine N-methyltransferase 2H
Protein Family:Hemolysin
UniProt Gene Name:ASH1L  
UniProt Entry Name:ASH1L_HUMAN
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