Anti-ASH1L Antibody (CAB20339)
- SKU:
- CAB20339
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- ASH1
- Synonyms:
- KMT2H
- Synonyms:
- MRD52
- Synonyms:
- ASH1L1
Description
| Product Name: | ASH1L Rabbit pAb |
| Product Code: | CAB20339 |
| Size: | 50uL, 100uL |
| Synonyms: | ASH1, KMT2H, MRD52, ASH1L1 |
| Applications: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 2074-2293 of human ASH1L (NP_060959.2). |
| Applications: | WB |
| Recommended Dilutions: | WB 1:1000 - 1:2000 |
| Reactivity: | Human |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 2074-2293 of human ASH1L (NP_060959.2). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 55870 |
| Uniprot: | Q9NR48 |
| Calculated MW: | 332kDa |
| Observed MW: | Refer to figures |
| UniProt Protein Function: | ASH1L: a protein methyltransferase that specifically methylates K36 of histone H3 (H3K36me). A member of the trithorax group (trxG) of transcriptional activators that is required for proper expression of Hox genes and is preferentially expressed in haematopoietic stem cells. Widely expressed, with high levels in brain, heart and kidney. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions. Protein type: Cell adhesion; EC 2.1.1.43; Amino Acid Metabolism - lysine degradation; Methyltransferase, protein lysine; Methyltransferase Chromosomal Location of Human Ortholog: 1q22 Cellular Component: nucleoplasm; Golgi apparatus; tight junction; cytoplasm; chromosome; nucleus Molecular Function: DNA binding; zinc ion binding; histone lysine N-methyltransferase activity (H3-K4 specific); chromatin binding Biological Process: transcription from RNA polymerase II promoter; cell-cell signaling; negative regulation of MAPKKK cascade; interleukin-6 production; histone H3-K4 methylation; negative regulation of acute inflammatory response; positive regulation of transcription from RNA polymerase II promoter; negative regulation of I-kappaB kinase/NF-kappaB cascade; DNA packaging |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the trithorax group of transcriptional activators. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NR48 |
| NCBI GenInfo Identifier: | 7739725 |
| NCBI Gene ID: | 55870 |
| NCBI Accession: | AAF68983.1 |
| UniProt Secondary Accession: | Q9NR48,Q59GP1, Q5T714, Q5T715, Q9P2C7 |
| UniProt Related Accession: | Q9NR48 |
| Molecular Weight: | |
| NCBI Full Name: | ASH1 |
| NCBI Synonym Full Names: | ash1 (absent, small, or homeotic)-like (Drosophila) |
| NCBI Official Symbol: | ASH1L |
| NCBI Official Synonym Symbols: | ASH1; KMT2H; ASH1L1 |
| NCBI Protein Information: | histone-lysine N-methyltransferase ASH1L |
| UniProt Protein Name: | Histone-lysine N-methyltransferase ASH1L |
| UniProt Synonym Protein Names: | ASH1-like protein; huASH1; Absent small and homeotic disks protein 1 homolog; Lysine N-methyltransferase 2H |
| Protein Family: | Hemolysin |
| UniProt Gene Name: | ASH1L |
| UniProt Entry Name: | ASH1L_HUMAN |
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