Cell Biology Antibodies 4
Anti-ASGR2 Antibody (CAB13949)
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- SKU:
- CAB13949
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ASGR2 Antibody |
| Antibody SKU: | CAB13949 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 131-287 of human ASGR2 (NP_550435.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse liver, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 131-287 of human ASGR2 (NP_550435.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VDLR FVAC QMEL LHSN GSQR TCCP VNWV EHQG SCYW FSHS GKAW AEAE KYCQ LENA HLVV INSW EEQK FIVQ HTNP FNTW IGLT DSDG SWKW VDGT DYRH NYKN WAVT QPDN WHGH ELGG SEDC VEVQ PDGR WNDD FCLQ VYRW VCEK RRNA TGEV A |
| Gene ID: | 433 |
| Uniprot: | P07307 |
| Cellular Location: | Membrane, Single-pass type II membrane protein |
| Calculated MW: | 32kDa/35kDa |
| Observed MW: | 38kDa |
| Synonyms: | ASGR2, ASGP-R2, ASGPR2, CLEC4H2, HBXBP, HL-2 |
| Background: | This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| UniProt Protein Function: | ASGP-R: cell surface receptor that mediates the endocytosis of plasma glycoproteins in which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. It transports these glycoproteins via a series of membrane vesicles and tubules to an acidic-sorting organelle where the receptor and ligand dissociates. Then the receptor is recycled back to the cell surface. There are four alternatively spliced transcript variants of this gene. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 17p13.1 Cellular Component: plasma membrane Molecular Function:asialoglycoprotein receptor activity; protein binding Biological Process: cell surface receptor linked signal transduction; protein amino acid N-linked glycosylation via asparagine |
| NCBI Summary: | This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011] |
| UniProt Code: | P07307 |
| NCBI GenInfo Identifier: | 218511923 |
| NCBI Gene ID: | 433 |
| NCBI Accession: | P07307.2 |
| UniProt Secondary Accession: | P07307,O00448, Q03969, A6NLV8, A8MT12, D3DTM9, D3DTN0 |
| UniProt Related Accession: | P07307 |
| Molecular Weight: | 35kDa |
| NCBI Full Name: | Asialoglycoprotein receptor 2 |
| NCBI Synonym Full Names: | asialoglycoprotein receptor 2 |
| NCBI Official Symbol: | ASGR2 |
| NCBI Official Synonym Symbols: | HL-2; HBXBP; ASGPR2; ASGP-R2; CLEC4H2 |
| NCBI Protein Information: | asialoglycoprotein receptor 2 |
| UniProt Protein Name: | Asialoglycoprotein receptor 2 |
| UniProt Synonym Protein Names: | C-type lectin domain family 4 member H2; Hepatic lectin H2; HL-2 |
| Protein Family: | Asialoglycoprotein receptor |
| UniProt Gene Name: | ASGR2 |
 | Western blot analysis of extracts of various cell lines, using ASGR2 Antibody (CAB13949) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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