Cell Biology Antibodies 10

Anti-ASGR1 Antibody (CAB6871)

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SKU:
CAB6871
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-ASGR1 Antibody
Antibody SKU:CAB6871
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human ASGR1 (NP_001662.1).
Application:WB IHC
Recommended Dilution:WB 1:1000 - 1:4000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, U-937, Mouse liver, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human ASGR1 (NP_001662.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MTKE YQDL QHLD NEES DHHQ LRKG PPPP QPLL QRLC SGPR LLLL SLGL SLLL LVVV CVIG SQNS QLQE ELRG LRET FSNF TAST EAQV KGLS TQGG NVGR KMKS LESQ LEKQ QKDL SEDH SSLL LHVK QFVS DLRS LSCQ MAAL QGNG SE
Gene ID:432
Uniprot:P07306
Cellular Location:Membrane, Secreted, Single-pass type II membrane protein
Calculated MW:29kDa/33kDa
Observed MW:39kDa
Synonyms:ASGR1, ASGPR, ASGPR1, CLEC4H1, HL-1
Background:This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
UniProt Protein Function:ASGR1: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 17p13.2

Cellular Component: integral to plasma membrane; extracellular region

Molecular Function:protein binding; protein homodimerization activity; metal ion binding; asialoglycoprotein receptor activity; carbohydrate binding

Biological Process: receptor-mediated endocytosis; cellular response to extracellular stimulus

NCBI Summary:This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
UniProt Code:P07306
NCBI GenInfo Identifier:308387363
NCBI Gene ID:432
NCBI Accession:NP_001184145.1
UniProt Secondary Accession:P07306,I3L1X1,
UniProt Related Accession:P07306
Molecular Weight:Observed MW: 39kDaCalculated MW: 29kDa/33kDa
NCBI Full Name:asialoglycoprotein receptor 1 isoform b
NCBI Synonym Full Names:asialoglycoprotein receptor 1
NCBI Official Symbol:ASGR1  
NCBI Official Synonym Symbols:HL-1; ASGPR; ASGPR1; CLEC4H1  
NCBI Protein Information:asialoglycoprotein receptor 1; hepatic lectin H1; C-type lectin domain family 4 member H1
UniProt Protein Name:Asialoglycoprotein receptor 1
UniProt Synonym Protein Names:C-type lectin domain family 4 member H1; Hepatic lectin H1; HL-1
Protein Family:Asialoglycoprotein receptor
UniProt Gene Name:ASGR1  
UniProt Entry Name:ASGR1_HUMAN
Anti-ASGR1 Antibody (CAB6871)Western blot analysis of extracts of various cell lines, using ASGR1 antibody (CAB6871) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
Anti-ASGR1 Antibody (CAB6871)Immunohistochemistry of paraffin-embedded human liver damage using ASGR1 antibody (CAB6871) at dilution of 1:100 (40x lens).
Anti-ASGR1 Antibody (CAB6871)Immunohistochemistry of paraffin-embedded human colon carcinoma using ASGR1 antibody (CAB6871) at dilution of 1:100 (40x lens).
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