Cell Biology Antibodies 14
Anti-ASGR1 Antibody (CAB16766)
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- SKU:
- CAB16766
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ASGR1 Antibody |
| Antibody SKU: | CAB16766 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human ASGR1. |
| Application: | IHC |
| Recommended Dilution: | IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant protein of human ASGR1. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 432 |
| Uniprot: | P07306 |
| Cellular Location: | Membrane, Secreted, Single-pass type II membrane protein |
| Calculated MW: | 29kDa/33kDa |
| Observed MW: | Refer to figures |
 | Immunohistochemistry - ASGR1 Rabbit pAb (CAB16766) |
| Synonyms: | ASGR1, ASGPR, ASGPR1, CLEC4H1, HL-1 |
| Background: | This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| UniProt Protein Function: | ASGR1: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 17p13.2 Cellular Component: integral to plasma membrane; extracellular region Molecular Function:protein binding; protein homodimerization activity; metal ion binding; asialoglycoprotein receptor activity; carbohydrate binding Biological Process: receptor-mediated endocytosis; cellular response to extracellular stimulus |
| NCBI Summary: | This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011] |
| UniProt Code: | P07306 |
| NCBI GenInfo Identifier: | 308387363 |
| NCBI Gene ID: | 432 |
| NCBI Accession: | NP_001184145.1 |
| UniProt Secondary Accession: | P07306,I3L1X1, |
| UniProt Related Accession: | P07306 |
| Molecular Weight: | Observed MW: 39kDaCalculated MW: 29kDa/33kDa |
| NCBI Full Name: | asialoglycoprotein receptor 1 isoform b |
| NCBI Synonym Full Names: | asialoglycoprotein receptor 1 |
| NCBI Official Symbol: | ASGR1 |
| NCBI Official Synonym Symbols: | HL-1; ASGPR; ASGPR1; CLEC4H1 |
| NCBI Protein Information: | asialoglycoprotein receptor 1; hepatic lectin H1; C-type lectin domain family 4 member H1 |
| UniProt Protein Name: | Asialoglycoprotein receptor 1 |
| UniProt Synonym Protein Names: | C-type lectin domain family 4 member H1; Hepatic lectin H1; HL-1 |
| Protein Family: | Asialoglycoprotein receptor |
| UniProt Gene Name: | ASGR1 |
| UniProt Entry Name: | ASGR1_HUMAN |
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