Epigenetics & Nuclear Signaling Antibodies 4
Anti-ASF1A Antibody (CAB6528)
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- SKU:
- CAB6528
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-ASF1A Antibody |
| Antibody SKU: | CAB6528 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-204 of human ASF1A (NP_054753.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Mouse pancreas |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-204 of human ASF1A (NP_054753.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAKV QVNN VVVL DNPS PFYN PFQF EITF ECIE DLSE DLEW KIIY VGSA ESEE YDQV LDSV LVGP VPAG RHMF VFQA DAPN PGLI PDAD AVGV TVVL ITCT YRGQ EFIR VGYY VNNE YTET ELRE NPPV KPDF SKLQ RNIL ASNP RVTR FHIN WEDN TEKL EDAE SSNP NLQS LLST DALP SASK GWST SENS LNVM LESH MDCM |
| Gene ID: | 25842 |
| Uniprot: | Q9Y294 |
| Cellular Location: | Nucleus |
| Calculated MW: | 22kDa |
| Observed MW: | 23kDa |
| Synonyms: | ASF1A, CGI-98, CIA, HSPC146 |
| Background: | This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair. |
| UniProt Protein Function: | ASF1A: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. Interacts with histone H3 (including both histone H3.1 and H3.3) and histone H4. Interacts with the CHAF1A, CHAF1B and RBBP4 subunits of the CAF-1 complex. Interacts with CABIN1, HAT1, HIRA, NASP, TAF1, TLK1, TLK2 and UBN1. Ubiquitously expressed. Belongs to the ASF1 family. |
| UniProt Protein Details: | Protein type:DNA repair, damage; Histone-binding Chromosomal Location of Human Ortholog: 6q22.31 Cellular Component: nuclear chromatin; nucleoplasm; nucleus; protein complex Molecular Function:chromatin binding; histone binding; protein binding Biological Process: chromatin modification; DNA repair; DNA replication-dependent nucleosome assembly; DNA replication-independent nucleosome assembly; muscle cell differentiation; negative regulation of chromatin silencing; nucleosome assembly; osteoblast differentiation; transcription, DNA-dependent |
| NCBI Summary: | This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y294 |
| NCBI GenInfo Identifier: | 74735206 |
| NCBI Gene ID: | 25842 |
| NCBI Accession: | Q9Y294.1 |
| UniProt Secondary Accession: | Q9Y294,Q6IA08, Q9P014, |
| UniProt Related Accession: | Q9Y294 |
| Molecular Weight: | 22,969 Da |
| NCBI Full Name: | Histone chaperone ASF1A |
| NCBI Synonym Full Names: | anti-silencing function 1A histone chaperone |
| NCBI Official Symbol: | ASF1A |
| NCBI Official Synonym Symbols: | CIA; CGI-98; HSPC146 |
| NCBI Protein Information: | histone chaperone ASF1A |
| UniProt Protein Name: | Histone chaperone ASF1A |
| UniProt Synonym Protein Names: | Anti-silencing function protein 1 homolog A; hAsf1; hAsf1a; CCG1-interacting factor A; CIA; hCIA |
| Protein Family: | Histone chaperone |
| UniProt Gene Name: | ASF1A |
| UniProt Entry Name: | ASF1A_HUMAN |
 | Western blot analysis of extracts of mouse pancreas, using ASF1A Antibody (CAB6528) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 20s. |
 | Immunofluorescence analysis of HeLa cells using ASF1A antibody (CAB6528). Blue: DAPI for nuclear staining. |
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