Epigenetics & Nuclear Signaling Antibodies 3
Anti-ASF1A Antibody (CAB14508)
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- SKU:
- CAB14508
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-ASF1A Antibody |
| Antibody SKU: | CAB14508 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-204 of human ASF1A (NP_054753.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-204 of human ASF1A (NP_054753.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TYRG QEFI RVGY YVNN EYTE TELR ENPP VKPD FSKL QRNI LASN PRVT RFHI NWED NTEK LEDA ESSN PNLQ SLLS TDAL PSAS KGWS TSEN SLNV MLES HMDC M |
| Gene ID: | 25842 |
| Uniprot: | Q9Y294 |
| Cellular Location: | Nucleus |
| Calculated MW: | 22kDa |
| Observed MW: | Refer to Figures |
| Synonyms: | ASF1A, CGI-98, CIA, HSPC146 |
| Background: | This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair. |
| UniProt Protein Function: | ASF1A: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. Interacts with histone H3 (including both histone H3.1 and H3.3) and histone H4. Interacts with the CHAF1A, CHAF1B and RBBP4 subunits of the CAF-1 complex. Interacts with CABIN1, HAT1, HIRA, NASP, TAF1, TLK1, TLK2 and UBN1. Ubiquitously expressed. Belongs to the ASF1 family. |
| UniProt Protein Details: | Protein type:DNA repair, damage; Histone-binding Chromosomal Location of Human Ortholog: 6q22.31 Cellular Component: nuclear chromatin; nucleoplasm; nucleus; protein complex Molecular Function:chromatin binding; histone binding; protein binding Biological Process: chromatin modification; DNA repair; DNA replication-dependent nucleosome assembly; DNA replication-independent nucleosome assembly; muscle cell differentiation; negative regulation of chromatin silencing; nucleosome assembly; osteoblast differentiation; transcription, DNA-dependent |
| NCBI Summary: | This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y294 |
| NCBI GenInfo Identifier: | 74735206 |
| NCBI Gene ID: | 25842 |
| NCBI Accession: | Q9Y294.1 |
| UniProt Secondary Accession: | Q9Y294,Q6IA08, Q9P014, |
| UniProt Related Accession: | Q9Y294 |
| Molecular Weight: | 22,969 Da |
| NCBI Full Name: | Histone chaperone ASF1A |
| NCBI Synonym Full Names: | anti-silencing function 1A histone chaperone |
| NCBI Official Symbol: | ASF1A |
| NCBI Official Synonym Symbols: | CIA; CGI-98; HSPC146 |
| NCBI Protein Information: | histone chaperone ASF1A |
| UniProt Protein Name: | Histone chaperone ASF1A |
| UniProt Synonym Protein Names: | Anti-silencing function protein 1 homolog A; hAsf1; hAsf1a; CCG1-interacting factor A; CIA; hCIA |
| Protein Family: | Histone chaperone |
| UniProt Gene Name: | ASF1A |
| UniProt Entry Name: | ASF1A_HUMAN |
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