Epigenetics & Nuclear Signaling Antibodies 4

Anti-ASCC3 Antibody (CAB7960)

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SKU:
CAB7960
Product Type:
Antibody
Applications:
WB
Applications:
IF
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:ASCC3 Rabbit Polyclonal Antibody
Antibody SKU:CAB7960
Antibody Size:20uL, 50uL, 100uL
Application:IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-111 of human ASCC3 (NP_071374.1).
Application:IF
Recommended Dilution:IF 1:50 - 1:100
Reactivity:Human, Mouse
Positive Samples:293T, Jurkat, HeLa, NCI-H460, Mouse liver, Mouse spleen, Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-111 of human ASCC3 (NP_071374.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MALP RLTG ALRS FSNV TKQD NYNE EVAD LKIK RSKL HEQV LDLG LTWK KIIK FLNE KLEK SKMQ SINE DLKD ILHA AKQI EVNC PFQK RRLD GKEE DEKM SRAS DRFR GLR
Gene ID:10973
Uniprot:Q8N3C0
Cellular Location:Cytoplasm, Nucleus
Calculated MW:13kDa/83kDa/251kDa
Observed MW:Refer to figures
Synonyms:ASCC3, ASC1p200, HELIC1, RNAH
Background:This gene encodes a protein that belongs to a family of helicases that are involved in the ATP-dependent unwinding of nucleic acid duplexes. The encoded protein is the largest subunit of the activating signal cointegrator 1 complex that is involved in DNA repair and resistance to alkylation damage. Alternate splicing results in multiple transcript variants.
UniProt Protein Function:ASCC3: 3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3- methylcytosine (3mC) within double-stranded regions. Enhances NF- kappa-B, SRF and AP1 transactivation. Belongs to the helicase family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 3.6.4.12; Helicase; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 6q16

Cellular Component: Golgi apparatus; membrane; cytoplasm; intracellular; nucleus

Molecular Function:protein binding; ATP-dependent 3'-5' DNA helicase activity; ATP binding

Biological Process: cell proliferation; DNA dealkylation; transcription, DNA-dependent; regulation of transcription, DNA-dependent; DNA duplex unwinding

NCBI Summary:This gene encodes a protein that belongs to a family of helicases that are involved in the ATP-dependent unwinding of nucleic acid duplexes. The encoded protein is the largest subunit of the activating signal cointegrator 1 complex that is involved in DNA repair and resistance to alkylation damage. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
UniProt Code:Q8N3C0
NCBI GenInfo Identifier:158518649
NCBI Gene ID:10973
NCBI Accession:Q8N3C0.3
UniProt Related Accession:Q8N3C0
Molecular Weight:160kDa
NCBI Full Name:Activating signal cointegrator 1 complex subunit 3
NCBI Synonym Full Names:activating signal cointegrator 1 complex subunit 3
NCBI Official Symbol:ASCC3  
NCBI Official Synonym Symbols:RNAH; HELIC1; ASC1p200  
NCBI Protein Information:activating signal cointegrator 1 complex subunit 3
UniProt Protein Name:Activating signal cointegrator 1 complex subunit 3
UniProt Synonym Protein Names:ASC-1 complex subunit p200; ASC1p200; Helicase, ATP binding 1; Trip4 complex subunit p200
Protein Family:Activating signal cointegrator 1 complex
UniProt Gene Name:ASCC3  
UniProt Entry Name:ASCC3_HUMAN
Anti-ASCC3 Polyclonal Antibody (CAB7960)Immunofluorescence analysis of A549 cells using ASCC3 antibody (CAB7960). Blue: DAPI for nuclear staining.
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