Epigenetics & Nuclear Signaling Antibodies 4
Anti-ASCC3 Antibody (CAB7960)
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- SKU:
- CAB7960
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IF
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | ASCC3 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB7960 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-111 of human ASCC3 (NP_071374.1). |
| Application: | IF |
| Recommended Dilution: | IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse |
| Positive Samples: | 293T, Jurkat, HeLa, NCI-H460, Mouse liver, Mouse spleen, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-111 of human ASCC3 (NP_071374.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MALP RLTG ALRS FSNV TKQD NYNE EVAD LKIK RSKL HEQV LDLG LTWK KIIK FLNE KLEK SKMQ SINE DLKD ILHA AKQI EVNC PFQK RRLD GKEE DEKM SRAS DRFR GLR |
| Gene ID: | 10973 |
| Uniprot: | Q8N3C0 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 13kDa/83kDa/251kDa |
| Observed MW: | Refer to figures |
| Synonyms: | ASCC3, ASC1p200, HELIC1, RNAH |
| Background: | This gene encodes a protein that belongs to a family of helicases that are involved in the ATP-dependent unwinding of nucleic acid duplexes. The encoded protein is the largest subunit of the activating signal cointegrator 1 complex that is involved in DNA repair and resistance to alkylation damage. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | ASCC3: 3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3- methylcytosine (3mC) within double-stranded regions. Enhances NF- kappa-B, SRF and AP1 transactivation. Belongs to the helicase family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.6.4.12; Helicase; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 6q16 Cellular Component: Golgi apparatus; membrane; cytoplasm; intracellular; nucleus Molecular Function:protein binding; ATP-dependent 3'-5' DNA helicase activity; ATP binding Biological Process: cell proliferation; DNA dealkylation; transcription, DNA-dependent; regulation of transcription, DNA-dependent; DNA duplex unwinding |
| NCBI Summary: | This gene encodes a protein that belongs to a family of helicases that are involved in the ATP-dependent unwinding of nucleic acid duplexes. The encoded protein is the largest subunit of the activating signal cointegrator 1 complex that is involved in DNA repair and resistance to alkylation damage. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] |
| UniProt Code: | Q8N3C0 |
| NCBI GenInfo Identifier: | 158518649 |
| NCBI Gene ID: | 10973 |
| NCBI Accession: | Q8N3C0.3 |
| UniProt Related Accession: | Q8N3C0 |
| Molecular Weight: | 160kDa |
| NCBI Full Name: | Activating signal cointegrator 1 complex subunit 3 |
| NCBI Synonym Full Names: | activating signal cointegrator 1 complex subunit 3 |
| NCBI Official Symbol: | ASCC3 |
| NCBI Official Synonym Symbols: | RNAH; HELIC1; ASC1p200 |
| NCBI Protein Information: | activating signal cointegrator 1 complex subunit 3 |
| UniProt Protein Name: | Activating signal cointegrator 1 complex subunit 3 |
| UniProt Synonym Protein Names: | ASC-1 complex subunit p200; ASC1p200; Helicase, ATP binding 1; Trip4 complex subunit p200 |
| Protein Family: | Activating signal cointegrator 1 complex |
| UniProt Gene Name: | ASCC3 |
| UniProt Entry Name: | ASCC3_HUMAN |
 | Immunofluorescence analysis of A549 cells using ASCC3 antibody (CAB7960). Blue: DAPI for nuclear staining. |
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