Cell Biology Antibodies 13

Anti-ASAP2 Antibody (CAB17579)

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SKU:
CAB17579
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-ASAP2 Antibody
Antibody SKU:CAB17579
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human ASAP2 (NP_001128663).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse lung, Mouse heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human ASAP2 (NP_001128663).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MPDQ ISVS EFVA ETHE DYKA PTAS SFTT RTAQ CRNT VAAI EEAL DVDR MVLY KMKK SVKA INSS GLAH VENE EQYT QALE KFGG NCVC RDDP DLGS AFLK FSVF TKEL TALF KNLI QNMN
Gene ID:8853
Uniprot:O43150
Cellular Location:
Calculated MW:
Observed MW:112kDa
Anti-ASAP2 Antibody (CAB17579)Western blot - ASAP2 Polyclonal Antibody (CAB17579)
Synonyms:AMAP2, CENTB3, DDEF2, PAG3, PAP, Pap-alpha, SHAG1, ASAP2
Background:This gene encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain. The protein localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). The encoded protein forms a stable complex with PYK2 in vivo. This interaction appears to be mediated by binding of its SH3 domain to the C-terminal proline-rich domain of PYK2. The encoded protein is tyrosine phosphorylated by activated PYK2. It has catalytic activity for class I and II ArfGAPs in vitro, and can bind the class III Arf ARF6 without immediate GAP activity. The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle budding when recruited to Golgi membranes. In addition, it functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
NCBI Summary:This gene encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain. The protein localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). The encoded protein forms a stable complex with PYK2 in vivo. This interaction appears to be mediated by binding of its SH3 domain to the C-terminal proline-rich domain of PYK2. The encoded protein is tyrosine phosphorylated by activated PYK2. It has catalytic activity for class I and II ArfGAPs in vitro, and can bind the class III Arf ARF6 without immediate GAP activity. The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle budding when recruited to Golgi membranes. In addition, it functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
UniProt Code:O43150
NCBI GenInfo Identifier:4502249
NCBI Gene ID:8853
NCBI Accession:NP_003878
UniProt Related Accession:O43150
Molecular Weight:112kDa
NCBI Full Name:arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform a
NCBI Synonym Full Names:ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
NCBI Official Symbol:ASAP2  
NCBI Official Synonym Symbols:PAP; PAG3; AMAP2; DDEF2; SHAG1; CENTB3; Pap-alpha  
NCBI Protein Information:arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2
UniProt Protein Name:Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2
UniProt Synonym Protein Names:Development and differentiation-enhancing factor 2; Paxillin-associated protein with ARF GAP activity 3; PAG3; Pyk2 C-terminus-associated protein; PAP
Protein Family:Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein
UniProt Gene Name:ASAP2  
UniProt Entry Name:ASAP2_HUMAN
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