Cell Biology Antibodies 6

Anti-ARSE Antibody (CAB15644)

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SKU:
CAB15644
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-ARSE Antibody
Antibody SKU:CAB15644
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 520-589 of human ARSE (NP_000038.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse liver, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 520-589 of human ARSE (NP_000038.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:PSET HILT PASE PVFY QVME RVQQ AVWE HQRT LSPV PLQL DRLG NIWR PWLQ PCCG PFPL CWCL REDD PQ
Gene ID:415
Uniprot:P51690
Cellular Location:Golgi apparatus, Golgi stack
Calculated MW:65kDa
Observed MW:75kDa
Synonyms:ARSE, ASE, CDPX, CDPX1, CDPXR
Background:Arylsulfatase E is a member of the sulfatase family. It is glycosylated postranslationally and localized to the golgi apparatus. Sulfatases are essential for the correct composition of bone and cartilage matrix. X-linked chondrodysplasia punctata, a disease characterized by abnormalities in cartilage and bone development, has been linked to mutations in this gene. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the Y chromosome.
UniProt Protein Function:ARSE: May be essential for the correct composition of cartilage and bone matrix during development. Has no activity toward steroid sulfates. Defects in ARSE are the cause of chondrodysplasia punctata X-linked recessive type 1 (CDPX1). CDP is a clinically and genetically heterogeneous disorder characterized by punctiform calcification of the bones. CDPX1 is a congenital defect of bone and cartilage development characterized by aberrant bone mineralization, severe underdevelopment of nasal cartilage, and distal phalangeal hypoplasia. This disease can also be induced by inhibition with the drug warfarin. Belongs to the sulfatase family.
UniProt Protein Details:

Protein type:Hydrolase; EC 3.1.6.-

Chromosomal Location of Human Ortholog: Xp22.3

Cellular Component: Golgi stack; endoplasmic reticulum lumen

Molecular Function:arylsulfatase activity; metal ion binding

Biological Process: cellular protein metabolic process; sphingolipid metabolic process; glycosphingolipid metabolic process; post-translational protein modification; skeletal development

Disease: Chondrodysplasia Punctata 1, X-linked Recessive

NCBI Summary:Arylsulfatase E is a member of the sulfatase family. It is glycosylated postranslationally and localized to the golgi apparatus. Sulfatases are essential for the correct composition of bone and cartilage matrix. X-linked chondrodysplasia punctata, a disease characterized by abnormalities in cartilage and bone development, has been linked to mutations in this gene. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the Y chromosome. [provided by RefSeq, Sep 2013]
UniProt Code:P51690
NCBI GenInfo Identifier:157266309
NCBI Gene ID:415
NCBI Accession:NP_000038.2
UniProt Related Accession:P51690
Molecular Weight:
NCBI Full Name:arylsulfatase L isoform 2
NCBI Synonym Full Names:arylsulfatase L
NCBI Official Symbol:ARSL  
NCBI Official Synonym Symbols:ASE; ARSE; CDPX; CDPX1; CDPXR  
NCBI Protein Information:arylsulfatase L; arylsulfatase E
UniProt Protein Name:Arylsulfatase E
Protein Family:Arylsulfatase
UniProt Gene Name:ARSE  
UniProt Entry Name:ARSE_HUMAN
Anti-ARSE Antibody (CAB15644)Western blot analysis of extracts of various cell lines, using ARSE antibody (CAB15644) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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