Cell Biology Antibodies 2

Anti-ARPC2 Antibody (CAB10791)

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SKU:
CAB10791
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-ARPC2 Antibody
Antibody SKU:CAB10791
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ARPC2 (NP_690601.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:A375, U-87MG, HT-29, SGC-7901, Mouse heart, Mouse lung, Mouse spleen, Mouse thymus, Rat heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ARPC2 (NP_690601.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MILL EVNN RIIE ETLA LKFE NAAA GNKP EAVE VTFA DFDG VLYH ISNP NGDK TKVM VSIS LKFY KELQ AHGA DELL KRVY GSFL VNPE SGYN VSLL YDLE NLPA SKDS IVHQ AGML KRNC FASV FEKY FQFQ EEGK EGEN RAVI HYRD DETM YVES KKDR VTVV FSTV FKDD DDVV IGKV FMQE FKEG RRAS HTAP QVLF SHRE PPLE LKDT DAAV GDNI GYIT FVLF PRHT NASA RDNT INLI HTFR DYLH YHIK CSKA YIHT RMRA KTSD FLKV LNRA RPDA EKKE MKTI TGKT FSSR
Gene ID:10109
Uniprot:O15144
Cellular Location:Cell junction, Cell projection, Cytoplasm, cytoskeleton, synapse, synaptosome
Calculated MW:34kDa
Observed MW:34kDa
Synonyms:ARPC2, ARC34, PNAS-139, PRO2446, p34-Arc
Background:This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined.
UniProt Protein Function:ARPC2: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament. Belongs to the ARPC2 family.
UniProt Protein Details:

Protein type:Actin-binding; Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 2q36.1

Cellular Component: Golgi apparatus; Arp2/3 protein complex; neuron projection; focal adhesion; cytoplasm; leading edge; plasma membrane; synapse; cytosol; endosome; actin cytoskeleton

Molecular Function:actin filament binding; protein binding; structural constituent of cytoskeleton; kinesin binding

Biological Process: axon guidance; ephrin receptor signaling pathway; innate immune response; cell motility

NCBI Summary:This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
UniProt Code:O15144
NCBI GenInfo Identifier:3121764
NCBI Gene ID:10109
NCBI Accession:O15144.1
UniProt Secondary Accession:O15144,Q92801, Q9P1D4,
UniProt Related Accession:O15144
Molecular Weight:34,333 Da
NCBI Full Name:Actin-related protein 2/3 complex subunit 2
NCBI Synonym Full Names:actin related protein 2/3 complex, subunit 2, 34kDa
NCBI Official Symbol:ARPC2  
NCBI Official Synonym Symbols:ARC34; PRO2446; p34-Arc; PNAS-139  
NCBI Protein Information:actin-related protein 2/3 complex subunit 2; ARP2/3 protein complex subunit 34; arp2/3 complex 34 kDa subunit
UniProt Protein Name:Actin-related protein 2/3 complex subunit 2
UniProt Synonym Protein Names:Arp2/3 complex 34 kDa subunit; p34-ARC
UniProt Gene Name:ARPC2  
UniProt Entry Name:ARPC2_HUMAN
Anti-ARPC2 Antibody (CAB10791)Western blot analysis of extracts of various cell lines, using ARPC2 antibody (CAB10791) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s.
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