Cell Biology Antibodies 14

Anti-ARPC1B Antibody (CAB17070)

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SKU:
CAB17070
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-ARPC1B Antibody
Antibody SKU:CAB17070
Antibody Size:20uL, 50 uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 10-80 of human ARPC1B (NP_005711.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 10-80 of human ARPC1B (NP_005711.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:PISC HAWN KDRT QIAI CPNN HEVH IYEK SGAK WTKV HELK EHNG QVTG IDWA PESN RIVT CGTD RNAY VWT
Gene ID:10095
Uniprot:O15143
Cellular Location:
Calculated MW:
Observed MW:Refer to figures
Synonyms:ARPC1B, ARC41, p40-ARC, p41-ARC
Background:This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase.
UniProt Protein Function:ARPC1B: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Belongs to the WD repeat ARPC1 family.
UniProt Protein Details:

Protein type:Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 7q22.1

Cellular Component: actin cytoskeleton; Arp2/3 protein complex; cytosol; focal adhesion

Molecular Function:actin filament binding; structural constituent of cytoskeleton

Biological Process: cell motility; ephrin receptor signaling pathway

NCBI Summary:This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase. [provided by RefSeq, Mar 2011]
UniProt Code:O15143
NCBI GenInfo Identifier:3121763
NCBI Gene ID:10095
NCBI Accession:O15143.3
UniProt Secondary Accession:O15143,Q9BU00,
UniProt Related Accession:O15143
Molecular Weight:40,950 Da
NCBI Full Name:Actin-related protein 2/3 complex subunit 1B
NCBI Synonym Full Names:actin related protein 2/3 complex subunit 1B
NCBI Official Symbol:ARPC1B  
NCBI Official Synonym Symbols:ARC41; p40-ARC; p41-ARC  
NCBI Protein Information:actin-related protein 2/3 complex subunit 1B
UniProt Protein Name:Actin-related protein 2/3 complex subunit 1B
UniProt Synonym Protein Names:Arp2/3 complex 41 kDa subunit; p41-ARC
Protein Family:Actin-related protein 2/3 complex
UniProt Gene Name:ARPC1B  
UniProt Entry Name:ARC1B_HUMAN
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