Cell Biology Antibodies 2
Anti-ARPC1A Antibody (CAB1070)
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- SKU:
- CAB1070
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ARPC1A Antibody |
| Antibody SKU: | CAB1070 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-370 of human ARPC1A (NP_006400.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | MCF7, THP-1, Raji |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-370 of human ARPC1A (NP_006400.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSLH QFLL EPIT CHAW NRDR TQIA LSPN NHEV HIYK KNGS QWVK AHEL KEHN GHIT GIDW APKS DRIV TCGA DRNA YVWS QKDG VWKP TLVI LRIN RAAT FVKW SPLE NKFA VGSG ARLI SVCY FESE NDWW VSKH IKKP IRST VLSL DWHP NNVL LAAG SCDF KCRV FSAY IKEV DEKP ASTP WGSK MPFG QLMS EFGG SGTG GWVH GVSF SASG SRLA WVSH DSTV SVAD ASKS VQVS TLKT EFLP LLSV SFVS ENSV VAAG HDCC PMLF NYDD RGCL TFVS KLDI PKQS IQRN MSAM ERFR NMDK RATT EDRN TALE TLHQ NSIT QVSI YEVD KQDC RKFC TTGI DGAM TIWD FKTL ESSI QGLR IM |
| Gene ID: | 10552 |
| Uniprot: | Q92747 |
| Cellular Location: | Cytoplasm, cytoskeleton |
| Calculated MW: | 38kDa/41kDa |
| Observed MW: | 43kDa |
| Synonyms: | ARPC1A, Arc40, HEL-68, HEL-S-307, SOP2Hs, SOP2L |
| Background: | This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | ARPC1A: Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Belongs to the WD repeat ARPC1 family. |
| UniProt Protein Details: | Protein type:Cytoskeletal; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 7q22.1 Cellular Component: Arp2/3 protein complex; cytosol; actin cytoskeleton Molecular Function:actin filament binding; actin binding Biological Process: axon guidance; ephrin receptor signaling pathway; innate immune response; actin cytoskeleton organization and biogenesis |
| NCBI Summary: | This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] |
| UniProt Code: | Q92747 |
| NCBI GenInfo Identifier: | 88984001 |
| NCBI Gene ID: | 10552 |
| NCBI Accession: | Q92747.2 |
| UniProt Related Accession: | Q92747 |
| Molecular Weight: | 38kDa; 41kDa |
| NCBI Full Name: | Actin-related protein 2/3 complex subunit 1A |
| NCBI Synonym Full Names: | actin related protein 2/3 complex subunit 1A |
| NCBI Official Symbol: | ARPC1A |
| NCBI Official Synonym Symbols: | Arc40; SOP2L; HEL-68; SOP2Hs; HEL-S-307 |
| NCBI Protein Information: | actin-related protein 2/3 complex subunit 1A |
| UniProt Protein Name: | Actin-related protein 2/3 complex subunit 1A |
| UniProt Synonym Protein Names: | SOP2-like protein |
| Protein Family: | Actin-related protein 2/3 complex |
| UniProt Gene Name: | ARPC1A |
| UniProt Entry Name: | ARC1A_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ARPC1A antibody (CAB1070) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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