Cell Biology Antibodies 17

Anti-Arp3 Antibody (CAB4514)

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SKU:
CAB4514
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
ARP3
Research Area:
Cell Biology

Description

Product Name:Arp3 Rabbit mAb
Product Code:CAB4514
Size:20uL, 50uL, 100uL
Synonyms:ARP3
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Arp3
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, Jurkat, U-251MG, Mouse lung, Mouse liver, Mouse spleen, Rat lung, Rat brain, Rat spleen
Immunogen:A synthesized peptide derived from human Arp3
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10096
Uniprot:P61158
Cellular Location:Cell projection, Cytoplasm, cytoskeleton
Calculated MW:47kDa
Observed MW:47KDa
UniProt Protein Function:Arp3: Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis. Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with WHDC1. Belongs to the actin family. ARP3 subfamily.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 2q14.1

Cellular Component: Golgi membrane; Arp2/3 protein complex; focal adhesion; hemidesmosome; membrane; lamellipodium; excitatory synapse; podosome; actin filament; intercellular junction; cytosol; actin cytoskeleton

Molecular Function:actin filament binding; protein binding; structural constituent of cytoskeleton; ATP binding

Biological Process: response to antibiotic; positive regulation of filopodium formation; axon guidance; meiotic chromosome movement towards spindle pole; asymmetric cell division; regulation of myosin II filament assembly or disassembly; establishment and/or maintenance of cell polarity; ephrin receptor signaling pathway; innate immune response; cytokinesis after meiosis; positive regulation of dendrite morphogenesis; cell motility; response to carbohydrate stimulus; spindle localization

NCBI Summary:The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]
UniProt Code:P61158
NCBI GenInfo Identifier:47117647
NCBI Gene ID:10096
NCBI Accession:P61158.3
UniProt Secondary Accession:P61158,P32391, Q53QM2,
UniProt Related Accession:P61158
Molecular Weight:47,371 Da
NCBI Full Name:Actin-related protein 3
NCBI Synonym Full Names:ARP3 actin-related protein 3 homolog (yeast)
NCBI Official Symbol:ACTR3  
NCBI Official Synonym Symbols:ARP3  
NCBI Protein Information:actin-related protein 3; actin-like protein 3
UniProt Protein Name:Actin-related protein 3
UniProt Synonym Protein Names:Actin-like protein 3
UniProt Gene Name:ACTR3  
UniProt Entry Name:ARP3_HUMAN
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