Cell Biology Antibodies 7

Anti-ARNTL Antibody (CAB17334)

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SKU:
CAB17334
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-ARNTL Antibody
Antibody SKU:CAB17334
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human ARNTL.
Application:WB
Recommended Dilution:WB 1:2000 - 1:5000
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, HeLa, 293T, mouse liver, rat testis
Immunogen:Recombinant protein of human ARNTL.
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:406
Uniprot:O003273
Cellular Location:
Calculated MW:81kDa
Observed MW:69kDa
Synonyms:ARNTL, BMAL1, BMAL1c, JAP3, MOP3, PASD3, TIC, bHLHe5, aryl hydrocarbon receptor nuclear translocator like, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1, CDW44, CSPG8, HCELL, HUTCH-I, ECMR-III
Background:The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis.
NCBI Summary:The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
UniProt Code:O003273
NCBI GenInfo Identifier:
NCBI Gene ID:
NCBI Accession:
UniProt Related Accession:O00327
Molecular Weight:81kDa
NCBI Full Name:
NCBI Synonym Full Names:aryl hydrocarbon receptor nuclear translocator like
NCBI Official Symbol:ARNTL  
NCBI Official Synonym Symbols:TIC; JAP3; MOP3; BMAL1; PASD3; BMAL1c; bHLHe5  
NCBI Protein Information:aryl hydrocarbon receptor nuclear translocator-like protein 1
UniProt Protein Name:
Protein Family:Aryl hydrocarbon receptor nuclear translocator-like protein
UniProt Gene Name:
Anti-ARNTL Antibody (CAB17334)Western blot analysis of extracts of various cell lines, using ARNTL antibody (CAB17334) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
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