Cell Biology Antibodies 18

Anti-ARL4C Antibody (CAB18311)

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SKU:
CAB18311
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-ARL4C Antibody
Antibody SKU:CAB18311
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human ARL4C.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:
Immunogen:Recombinant protein of human ARL4C.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10123
Uniprot:P56559
Cellular Location:
Calculated MW:21kDa
Observed MW:Refer to figures
Synonyms:ARL4C, ARL7, LAK
Background:ADP-ribosylation factor-like 4C is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4C is closely similar to ARL4A and ARL4D and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. This protein may play a role in cholesterol transport.
UniProt Protein Function:ARL4C: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. May be involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in the GDP- bound form. Regulates the microtubule-dependent intracellular vesicular transport from early endosome to recycling endosome process. Belongs to the small GTPase superfamily. Arf family.
UniProt Protein Details:

Protein type:G protein; G protein, monomeric, ARF; G protein, monomeric

Chromosomal Location of Human Ortholog: 2q37.1

Cellular Component: cytoplasm; plasma membrane; nucleus; filopodium

Molecular Function:GTPase activity; protein binding; GTP binding; alpha-tubulin binding

Biological Process: metabolic process; small GTPase mediated signal transduction; endocytic recycling

NCBI Summary:ADP-ribosylation factor-like 4C is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4C is closely similar to ARL4A and ARL4D and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. This protein may play a role in cholesterol transport. [provided by RefSeq, Jul 2008]
UniProt Code:P56559
NCBI GenInfo Identifier:540344578
NCBI Gene ID:10123
NCBI Accession:NP_001269360.1
UniProt Secondary Accession:P56559,Q4A519, Q53R10, Q9BVN1, Q9UQ34,
UniProt Related Accession:P56559
Molecular Weight:22,448 Da
NCBI Full Name:ADP-ribosylation factor-like protein 4C isoform 1
NCBI Synonym Full Names:ADP-ribosylation factor-like 4C
NCBI Official Symbol:ARL4C  
NCBI Official Synonym Symbols:LAK; ARL7  
NCBI Protein Information:ADP-ribosylation factor-like protein 4C; ADP-ribosylation factor-like 7; ADP ribosylation factor-like protein 7; ADP-ribosylation factor-like protein 7; ADP-ribosylation factor-like protein LAK
UniProt Protein Name:ADP-ribosylation factor-like protein 4C
UniProt Synonym Protein Names:ADP-ribosylation factor-like protein 7; ADP-ribosylation factor-like protein LAK
Protein Family:ADP-ribosylation factor-like protein
UniProt Gene Name:ARL4C  
UniProt Entry Name:ARL4C_HUMAN
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