Cell Cycle Antibodies 1
Anti-ARHGEF2 Antibody (CAB12547)
- SKU:
- CAB12547
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
| Antibody Name: | Anti-ARHGEF2 Antibody |
| Antibody SKU: | CAB12547 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IHC |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human ARHGEF2 (NP_004714.2). |
| Application: | IHC |
| Recommended Dilution: | IHC 1:50 - 1:100 |
| Reactivity: | Mouse |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human ARHGEF2 (NP_004714.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MKEA KDAR YTNG HLFT TISV SGMT MCYA CNKS ITAK EALI CPTC NVTI HNRC KDTL ANCT KVKQ KQQK AALL KNNT ALQS VSLR SKTT IRER PSSA IYPS DSFR QSLL GSRR GRSS LSLA KSVS TTNI AGHF NDES PLGL RRIL SQST DSLN MRNR TLSV ESLI DEEV IYSE LMSD FEMD EKDF AADS WSLA VDSS FLQQ HKKE VMKQ QDVI YELI QTEL HHVR TLKI MTRL FRTG MLEE LHLE PGVV QGLF PCVD ELSD IHTR FLSQ LLER RRQA LCPG STRN FVIH RLGD LLIS QFSG PSAE QMCK TYSE FCSR HSKA LKLY KELY ARDK RFQQ FIRK VTRP AVLK RH |
| Gene ID: | 9181 |
| Uniprot: | Q92974 |
| Cellular Location: | Cell junction, Cell projection, Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, cytoskeleton, ruffle membrane, spindle, tight junction |
| Calculated MW: | 108kDa/111kDa |
| Observed MW: |
| Synonyms: | GEF, GEF-H1, GEFH1, LFP40, P40, ARHGEF2, NEDMHM |
| Background: | Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified. |
| UniProt Protein Function: | ARHGEF2: a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases. Mediates cross-talk between microtubules and the actin cytoskeleton. Contains a phorbol esters/diacylglycerol binding and PH domain. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; GEFs, Rac/Rho; GEFs Chromosomal Location of Human Ortholog: 1q21-q22 Cellular Component: cell soma; cytoplasm; cytoplasmic membrane-bound vesicle; cytoskeleton; cytosol; dendritic shaft; focal adhesion; Golgi apparatus; microtubule; protein complex; spindle; tight junction; vesicle Molecular Function:microtubule binding; protein binding; Rac GTPase binding; Rac guanyl-nucleotide exchange factor activity; Rho GTPase binding; Rho guanyl-nucleotide exchange factor activity; transcription factor binding; zinc ion binding Biological Process: actin filament organization; activation of NF-kappaB transcription factor; cell division; cell morphogenesis; establishment of mitotic spindle orientation; innate immune response; intracellular protein transport; mitosis; negative regulation of microtubule depolymerization; negative regulation of neurogenesis; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; positive regulation of GTPase activity; positive regulation of interleukin-6 production; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; regulation of cell proliferation; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction |
| NCBI Summary: | Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009] |
| UniProt Code: | Q92974 |
| NCBI GenInfo Identifier: | 205830906 |
| NCBI Gene ID: | 9181 |
| NCBI Accession: | Q92974.4 |
| UniProt Secondary Accession: | Q92974,O75142, Q15079, Q5VY92, Q8TDA3, Q8WUG4, Q9H023 D3DVA6, |
| UniProt Related Accession: | Q92974 |
| Molecular Weight: | 108,242 Da |
| NCBI Full Name: | Rho guanine nucleotide exchange factor 2 |
| NCBI Synonym Full Names: | Rho/Rac guanine nucleotide exchange factor 2 |
| NCBI Official Symbol: | ARHGEF2 |
| NCBI Official Synonym Symbols: | GEF; P40; GEFH1; LFP40; GEF-H1 |
| NCBI Protein Information: | rho guanine nucleotide exchange factor 2 |
| UniProt Protein Name: | Rho guanine nucleotide exchange factor 2 |
| UniProt Synonym Protein Names: | Guanine nucleotide exchange factor H1; GEF-H1; Microtubule-regulated Rho-GEF; Proliferating cell nucleolar antigen p40 |
| Protein Family: | Rho guanine nucleotide exchange factor |
| UniProt Gene Name: | ARHGEF2 |
| UniProt Entry Name: | ARHG2_HUMAN |
 | Immunohistochemistry of paraffin-embedded mouse lung using ARHGEF2 antibody (CAB12547) at dilution of 1:100 (40x lens). |
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