Anti-Arginase 2 (ARG2) Antibody (CAB19233)
- SKU:
- CAB19233
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- ARG2
- Synonyms:
- arginase 2
- Research Area:
- Immunology
Description
| Product Name: | Arginase 2 (ARG2) Rabbit mAb |
| Product Code: | CAB19233 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | ARG2, arginase 2 |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human Arginase 2 (Arginase 2 (ARG2)). |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: | 293T |
| Immunogen: | Recombinant protein of human Arginase 2 (Arginase 2 (ARG2)). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 384 |
| Uniprot: | P78540 |
| Cellular Location: | Mitochondrion |
| Calculated MW: | 39kDa |
| Observed MW: | 40KDa |
| UniProt Protein Function: | ARG2: May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders. Belongs to the arginase family. |
| UniProt Protein Details: | Protein type:Hydrolase; Mitochondrial; EC 3.5.3.1; Amino Acid Metabolism - arginine and proline Chromosomal Location of Human Ortholog: 14q24.1 Cellular Component: mitochondrion; mitochondrial matrix Molecular Function:metal ion binding; arginase activity Biological Process: striated muscle contraction; arginine metabolic process; ureteric bud development; nitric oxide biosynthetic process; urea cycle |
| NCBI Summary: | Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P78540 |
| NCBI GenInfo Identifier: | 2492935 |
| NCBI Gene ID: | 384 |
| NCBI Accession: | P78540.1 |
| UniProt Secondary Accession: | P78540,Q6FHY8, B2R690, |
| UniProt Related Accession: | P78540 |
| Molecular Weight: | 354 |
| NCBI Full Name: | Arginase-2, mitochondrial |
| NCBI Synonym Full Names: | arginase 2 |
| NCBI Official Symbol: | ARG2 |
| NCBI Protein Information: | arginase-2, mitochondrial; kidney arginase; type II arginase; arginase, type II; nonhepatic arginase; kidney-type arginase; non-hepatic arginase; L-arginine ureahydrolase; L-arginine amidinohydrolase |
| UniProt Protein Name: | Arginase-2, mitochondrial |
| UniProt Synonym Protein Names: | Kidney-type arginase; Non-hepatic arginase; Type II arginase |
| Protein Family: | Arginase |
| UniProt Gene Name: | ARG2 |
| UniProt Entry Name: | ARGI2_HUMAN |
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