Immunology Antibodies 2
Anti-ARG2 Antibody (CAB6355)
- SKU:
- CAB6355
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-ARG2 Antibody |
| Antibody SKU: | CAB6355 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-354 of human ARG2 (NP_001163.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | BT-474, Mouse kidney, Mouse lung, Rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-354 of human ARG2 (NP_001163.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSLR GSLS RLLQ TRVH SILK KSVH SVAV IGAP FSQG QKRK GVEH GPAA IREA GLMK RLSS LGCH LKDF GDLS FTPV PKDD LYNN LIVN PRSV GLAN QELA EVVS RAVS DGYS CVTL GGDH SLAI GTIS GHAR HCPD LCVV WVDA HADI NTPL TTSS GNLH GQPV SFLL RELQ DKVP QLPG FSWI KPCI SSAS IVYI GLRD VDPP EHFI LKNY DIQY FSMR DIDR LGIQ KVME RTFD LLIG KRQR PIHL SFDI DAFD PTLA PATG TPVV GGLT YREG MYIA EEIH NTGL LSAL DLVE VNPQ LATS EEEA KTTA NLAV DVIA SSFG QTRE GGHI VYDQ LPTP SSPD ESEN QARV RI |
| Gene ID: | 384 |
| Uniprot: | P78540 |
| Cellular Location: | Mitochondrion |
| Calculated MW: | 38kDa |
| Observed MW: | 39kDa |
| Synonyms: | ARG2 |
| Background: | Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. |
| UniProt Protein Function: | ARG2: May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders. Belongs to the arginase family. |
| UniProt Protein Details: | Protein type:Hydrolase; Mitochondrial; EC 3.5.3.1; Amino Acid Metabolism - arginine and proline Chromosomal Location of Human Ortholog: 14q24.1 Cellular Component: mitochondrion; mitochondrial matrix Molecular Function:metal ion binding; arginase activity Biological Process: striated muscle contraction; arginine metabolic process; ureteric bud development; nitric oxide biosynthetic process; urea cycle |
| NCBI Summary: | Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P78540 |
| NCBI GenInfo Identifier: | 2492935 |
| NCBI Gene ID: | 384 |
| NCBI Accession: | P78540.1 |
| UniProt Secondary Accession: | P78540,Q6FHY8, B2R690, |
| UniProt Related Accession: | P78540 |
| Molecular Weight: | 354 |
| NCBI Full Name: | Arginase-2, mitochondrial |
| NCBI Synonym Full Names: | arginase 2 |
| NCBI Official Symbol: | ARG2 |
| NCBI Protein Information: | arginase-2, mitochondrial; kidney arginase; type II arginase; arginase, type II; nonhepatic arginase; kidney-type arginase; non-hepatic arginase; L-arginine ureahydrolase; L-arginine amidinohydrolase |
| UniProt Protein Name: | Arginase-2, mitochondrial |
| UniProt Synonym Protein Names: | Kidney-type arginase; Non-hepatic arginase; Type II arginase |
| Protein Family: | Arginase |
| UniProt Gene Name: | ARG2 |
| UniProt Entry Name: | ARGI2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ARG2 antibody (CAB6355) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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