Cell Biology Antibodies 7
Anti-ARFGEF1 Antibody (CAB16483)
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- SKU:
- CAB16483
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ARFGEF1 Antibody |
| Antibody SKU: | CAB16483 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 220-420 of human ARFGEF1 (NP_006412.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | U-87MG, BxPC-3 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 220-420 of human ARFGEF1 (NP_006412.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MEKE RHRQ HHHL LQSP VSHH EPES PQLR YLPP QTVD HISQ EHEG DLDL HTND VDKS LQDD TEPE NGSD ISSA ENEQ TEAD QATA AETL SKNE VLYD GENH DCEE KPQD IVQN IVEE MVNI VVGD MGEG TTIN ASAD GNIG TIED GSDS ENIQ ANGI PGTP ISVA YTPS LPDD RLSV SSND TQES GNSS GPSP GAKF SHIL Q |
| Gene ID: | 10565 |
| Uniprot: | Q9Y6D6 |
| Cellular Location: | Cytoplasm, Golgi apparatus, Membrane, Nucleus, Nucleus matrix, nucleolus, perinuclear region, trans-Golgi network |
| Calculated MW: | 208kDa |
| Observed MW: | 200kDa |
| Synonyms: | ARFGEF1, ARFGEP1, BIG1, P200 |
| Background: | ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for guanine-nucleotide exchange activity and also brefeldin A inhibition. |
| UniProt Code: | Q9Y6D6 |
| NCBI GenInfo Identifier: | 51479145 |
| NCBI Gene ID: | 10565 |
| NCBI Accession: | NP_006412.2 |
| UniProt Secondary Accession: | Q9Y6D6,Q9NV46, Q9UFV2, Q9UNL0, |
| UniProt Related Accession: | Q59FY5,Q9Y6D6 |
| Molecular Weight: | 208,767 Da |
| NCBI Full Name: | brefeldin A-inhibited guanine nucleotide-exchange protein 1 |
| NCBI Synonym Full Names: | ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited) |
| NCBI Official Symbol: | ARFGEF1 |
| NCBI Official Synonym Symbols: | BIG1; P200; ARFGEP1; DKFZP434L057; D730028O18Rik |
| NCBI Protein Information: | brefeldin A-inhibited guanine nucleotide-exchange protein 1; p200 ARF-GEP1; OTTHUMP00000227052; OTTHUMP00000227095; brefeldin A-inhibited GEP 1; p200 ARF guanine nucleotide exchange factor |
| UniProt Protein Name: | Brefeldin A-inhibited guanine nucleotide-exchange protein 1 |
| UniProt Synonym Protein Names: | p200 ARF guanine nucleotide exchange factor; p200 ARF-GEP1 |
| Protein Family: | Brefeldin A-inhibited guanine nucleotide-exchange protein |
| UniProt Gene Name: | ARFGEF1 |
| UniProt Entry Name: | BIG1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ARFGEF1 antibody (CAB16483) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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